Current Status and New Drugs Progress in the Treatment of Relapsed and Refractory Acute Myeloid Leukemia--Review.
10.19746/j.cnki.issn.1009-2137.2022.06.044
- Author:
Wen-Feng LI
1
;
Jing-Bo ZHOU
1
;
Yan-Hong ZHAO
2
;
Hong-Juan YU
3
Author Information
1. Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
2. Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China .E-mail: cityhrb@163.com.
3. Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China E-mail: yuhongjuan2008@163.com.
- Publication Type:Journal Article
- Keywords:
hematopoietic stem cell transplantation;
immunotherapy;
molecular targeted drugs;
relapse and refractory acute myeloid leukemia
- MeSH:
Humans;
Leukemia, Myeloid, Acute/drug therapy*
- From:
Journal of Experimental Hematology
2022;30(6):1907-1911
- CountryChina
- Language:Chinese
-
Abstract:
The overall therapeutic outcome of acute myeloid leukemia (AML) is poor, and relapse and refractory are the main reasons for treatment failure. Leukemia cells of relapsed and refractory AML (R/R-AML) patients are usually resistant to conventional chemotherapy, and new treatment regimens are urgently needed to further improve the survival rate and prolong the survival time of these patients.There are no recommended unified treatment regimens other than entering clinical trials.At present,the main options are salvage chemotherapy and hematopoietic stem cell transplantation (HSCT), and HSCT is the only possible cure for R/R-AML, but the prognosis of most of these patients is still poor.In recent years,the treatment status of AML has progressed rapidly, and the new therapies are emerging, many new drugs have become the research focus. Some progress has been made in improving chemosensitivity and overcoming chemoresistance by combining the new drugs with the original chemotherapeutic drugs, which provide a new treatment option and improve the overall prognosis for R/R-AML patients. This article will review the current treatment status and the latest progress in new drug research of R/R-AML.
