Multiple Cutaneous Edema and Infiltration of Signet-ring Cells in the Lymphatics as an Initial Manifestation of Metastatic Gastric Adenocarcinoma.
- Author:
Oh Eon KWON
1
;
Bon Seok KU
;
Dae Cheol KIM
;
Chae Wook LEE
;
Ki Ho KIM
Author Information
1. Department of Dermatology, College of Medicine, Dong-A University, Busan, Korea. hopekoo@hanmail.net
- Publication Type:Case Report
- Keywords:
Metastatic gastric adenocarcinoma;
Signet-ring cell
- MeSH:
Adenocarcinoma*;
Adult;
Breast;
Colloids;
Edema*;
Humans;
Iron;
Lung;
Lymph Nodes;
Neoplasm Metastasis;
Skin;
Stomach;
Stomach Neoplasms
- From:Korean Journal of Dermatology
2006;44(5):601-604
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Signet-ring cells are cells in which the nucleus is crescentically compressed with a cellular border, so that the cell looks like a signet-ring. Many cutaneous signet-ring cell neoplasms originate from the stomach, lung and breast, and these appear to be the most common sites of origin. In skin, the appearance of signet-ring cells within a neoplasm can indicate metastatic adenocarcinoma of the stomach, lung and breast. Thus, the primary origin and other metastatic sites should be evaluated. A 44-year-old man presented with a six month history of cutaneous swelling on the left axillary and left supraclavicular area. Histopathologic findings of the axillary lesion showed signet-ring cells in the lymphatics. These clustered cells were PAS-positive, diastase-resistant, and stained with colloidal iron and CEA. During the work-up study to find the primary origin, we discovered advanced gastric cancer and multiple lymph node metastases.
