Prognostic Value of A New Risk Stratification Model (R2-ISS) in Newly Diagnosed Multiple Myeloma.
10.19746/j.cnki.issn.1009-2137.2022.06.023
- Author:
Yin WANG
1
;
Ling-Ling YUE
1
;
Peng-Yun ZENG
1
;
Chong-Yang WU
1
;
Ye HAN
1
;
Ying SONG
1
;
Qi-Qi JIN
1
;
Hao-Yun JIANG
1
;
Ye CHAI
2
Author Information
1. Department of Hematology, Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province, China .
2. Department of Hematology, Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province, China .E-mail: papillon2009@163.com.
- Publication Type:Journal Article
- Keywords:
R2-ISS;
autologous hematopoietic stem cell transplantation;
multiple myeloma;
prognosis;
risk stratification
- MeSH:
Humans;
Prognosis;
Multiple Myeloma/diagnosis*;
Retrospective Studies;
Social Group;
Risk Assessment
- From:
Journal of Experimental Hematology
2022;30(6):1779-1784
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the significance of a new risk stratification model (R2-ISS) in evaluating the prognosis of newly diagnosed multiple myeloma (MM).
METHODS:Clinical data of 116 newly diagnosed MM patients admitted to Lanzhou University Second Hospital from June 2012 to March 2021 were retrospectively analyzed. According to R2-ISS, these patients were divided into four groups: low risk, low-intermediate risk, intermediate-high risk, and high risk. The significance of R2-ISS on prognosis of the patients was analyzed.
RESULTS:Survival analysis showed that R2-ISS was associated with progression-free survival (PFS) (P=0.042) and overall survival (OS) (P=0.014). Cox univariate analysis showed that lactate dehydrogenase, serum calcium, serum creatinine, β2-microglobulin, ISS, R-ISS, R2-ISS, t(4;14), and autologous hematopoietic stem cell transplantation (ASCT) were the influencing factors of OS in newly diagnosed MM patients (all P<0.05). Cox multivariate analysis showed that R-ISS, R2-ISS, and ASCT were independent risk factors affecting OS (all P<0.05). In addition, survival analysis of patients with different R2-ISS showed that ASCT improved PFS and OS.
CONCLUSION:R2-ISS has prognostic value for newly diagnosed MM patients, while ASCT can improve the prognosis of patients with different R2-ISS.
