Research Progress of Transmembrane Protein Abnormality in Non-Hodgkin's Lymphoma --Review.
10.19746/j.cnki.issn.1009-2137.2022.05.050
- Author:
Yi-Xian FU
1
;
Fei LI
2
Author Information
1. Hematology Medical Center of The First Affiliated Hospital of Nanchang University, Institute of Hematology, Academy of Clinical Medicine Sciences of Jiangxi Province, Institute of Lymphatic Tumor Diseases of Nanchang University, Nanchang 330006, Jiangxi Province, China.
2. Hematology Medical Center of The First Affiliated Hospital of Nanchang University, Institute of Hematology, Academy of Clinical Medicine Sciences of Jiangxi Province, Institute of Lymphatic Tumor Diseases of Nanchang University, Nanchang 330006, Jiangxi Province, China,E-mail: yx021021@sina.com.
- Publication Type:Review
- Keywords:
membrane proteins;
non-Hodgkin′s lymphoma;
suppressor gene;
tumor
- MeSH:
Humans;
Lipid Bilayers;
Lymphoma, Non-Hodgkin/therapy*;
Prognosis;
Programmed Cell Death 1 Receptor;
Sphingosine-1-Phosphate Receptors
- From:
Journal of Experimental Hematology
2022;30(5):1617-1621
- CountryChina
- Language:Chinese
-
Abstract:
Transmembrane protein, also known as integral membrane protein, can be distributed in the lipid bilayer or across the entire membrane, and it plays an important role in cell signal transduction. It has been discovered that multiple transmembrane proteins are involved in the regulation of tumor signals. Recent studies have revealed that the abnormal expression of some transmembrane protein is closely related to the occurrence, development and prognosis of non-Hodgkin's lymphoma (NHL), including programmed cell death protein 1 (PD-1), TMEM30A, NOTCH1, TOLL-like receptor (TLR), sphingosine-1-phosphate receptor, TRAIL, etc. The study on these transmembrane proteins and related genes has important clinical significance for the treatment and prognosis of NHL, and it may become a new therapeutic target. At present, there have been some research results in this field at home and abroad. This article reviewed the research progress of transmembrane protein that has inhibitory effects on NHL in recent years.
