Mechanisms of Extracellular Vesicles Involved in Multiple Myeloma --Review.
10.19746/j.cnki.issn.1009-2137.2022.05.049
- Author:
Yi-Hui GUO
1
;
Jia-Wei XU
1
;
Hui SONG
1
;
Qing ZENG
2
;
Wei-Min CHENG
3
Author Information
1. Graduate School of Guangxi University of Chinese Medicine, Nanning 530001， Guangxi Zhuang Autonomous Region, China.
2. Department of Hematology， The First Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530023， Guangxi Zhuang Autonomous Region， China.
3. Department of Hematology， The First Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530023， Guangxi Zhuang Autonomous Region， China,E-mail: cheng5min@126.com.
- Publication Type:Journal Article
- Keywords:
biomarker;
extracellular vesicle;
multiple myeloma
- MeSH:
Bone Marrow/metabolism*;
Extracellular Vesicles/pathology*;
Hematologic Neoplasms/metabolism*;
Humans;
Multiple Myeloma/pathology*;
Nucleic Acids/metabolism*;
Tumor Microenvironment
- From:
Journal of Experimental Hematology
2022;30(5):1612-1616
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma (MM) is a common hematologic tumor characterized by malignant proliferation of clonal plasma cells, the exact pathogenesis of which is not yet fully understood. The extracellular vesicles (EV) are structures released by cells into their surroundings that do not have a functional nucleus and can communicate between cells or deliver biologically active proteins and nucleic acids to target cells. EV play an important role in the interaction between myeloma cells and the bone marrow microenvironment, and they can promote MM progression. In this paper, we summarize the recent research progress in the mechanism of action of EV on MM in order to provide inspiration for exploring new strategies for MM treatment and prognostic stratification.
