Research Progress of Short Chain Fatty Acids in the Pathogenesis of Immune Thrombocytopenia--Review.
10.19746/j.cnki.issn.1009-2137.2022.04.053
- Author:
Xiao-Na LI
1
;
Wen QU
2
Author Information
1. Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
2. Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China. E-mail: quwentj923@sina.com.
- Publication Type:Review
- Keywords:
gut microbiota;
immune regulation;
immune thrombocytopenia;
intestinal barrier;
short-chain fatty acids
- MeSH:
Adolescent;
Fatty Acids, Volatile/metabolism*;
Gastrointestinal Microbiome;
Humans;
Intestines;
Purpura, Thrombocytopenic, Idiopathic
- From:
Journal of Experimental Hematology
2022;30(4):1296-1300
- CountryChina
- Language:Chinese
-
Abstract:
The gut microbiota is an important part of the human body, and it's also the largest genome in the human body. Recent studies on the gut microbiota have found that it plays an important role in human immune diseases. In recent years, the methods of sequencing gut microbiota has teen improved, thus dysregulation of the gut microbiota is found in many immune diseases, and the most widely studied mechanism is the short-chain fatty acids (SCFA), which is a metabolite of gut microbiota. The role of short-chain fatty acids in intestinal barrier, IgA immunity, dendritic cells and regulatory T cells has become increasingly clear. The mechanisms of short-chain fatty acids in regulating immunity and its role in the pathogenesis of immune thrombocytopenia were covered in this review, so as to provide a new idea for the treatment of immune thrombocytopenia in the future.
