Molecular Characteristics and Clinical Significance of IGH Gene Rearrangement in B-Cell Lymphoma--Review.
10.19746/j.cnki.issn.1009-2137.2022.04.052
- Author:
Yin LI
1
,
2
;
Fei LI
1
,
3
Author Information
1. Department of Hematology, The First Affiliated Hospital of Nanchang University； Institute of Hematology, Academy of Clinical Medicine of Jiangxi Province
2. Institute of Lymphatic Tumor Diseases of Nanchang University, Nanchang 330006, Jiangxi Province, China.
3. Institute of Lymphatic Tumor Diseases of Nanchang University, Nanchang 330006, Jiangxi Province, China .E-mail: yx021021@sina.com.
- Publication Type:Journal Article
- Keywords:
B-cell lymphoma;
IGH;
clinical significance;
gene rearrangement;
molecular characteristics
- MeSH:
Gene Rearrangement;
Humans;
Lymphoid Tissue/pathology*;
Lymphoma;
Lymphoma, B-Cell/genetics*;
Polymerase Chain Reaction
- From:
Journal of Experimental Hematology
2022;30(4):1291-1295
- CountryChina
- Language:Chinese
-
Abstract:
B-cell lymphoma is the most common malignant lymphoma, and its incidence is increasing year by year. Some types are often indistinguishable from the reactive lesions through morphology combined with immunohistochemistry, so other auxiliary diagnostic methods are urgently needed. Since B-cell lymphoma is caused by malignant transformation of IGH rearranged B cells, the molecular characteristics of rearranged B cells can be used as an important reference for differentiating benign and malignant proliferations of lymphatic tissues. With the development of molecular biology technology, the detection of clonal rearrangement of IGH plays an important role in the diagnosis, efficacy evaluation and prognosis evaluation of lymphoma. This paper focuses on the molecular characteristics and clinical significance of clonal rearrangement of IGH in B-cell lymphoma.
