Research Progress of Abnormal Iron Metabolism and Tumor of Lymphatic Hematopoiesis System --Review.
10.19746/j.cnki.issn.1009-2137.2022.04.049
- Author:
Qi-Tang HUANG
1
;
Yan-Li LI
2
,
3
Author Information
1. Department of Pathological Anatomy, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China.
2. Department of Pathological Anatomy, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China
3. Department of Pathology, Anhui Medical University First Hospital, Hefei 230022, Anhui Province, China. E-mail：liyanli_rainbow126@163.com.
- Publication Type:Journal Article
- Keywords:
ferroportin;
transferrin;
tumor of lymphatic hematopoiesis system;
iron metabolism;
serum ferritin
- MeSH:
Hematopoiesis;
Humans;
Iron/metabolism*;
Neoplasms;
Receptors, Transferrin/metabolism*;
Transferrin/metabolism*
- From:
Journal of Experimental Hematology
2022;30(4):1277-1280
- CountryChina
- Language:Chinese
-
Abstract:
Iron metabolism is the process of absorption, transport, storage and conversion and excretion of the essential trace element iron in living organisms. Normal iron metabolism tightly regulates iron content at the systemic and cellular levels through a variety of related proteins to prevent excessive free radicals from being generated during the iron cycle that can damage the body. Various abnormalities in iron metabolism are found in a variety of lymphohaematopoietic tumours and an insidious link between iron metabolism and tumour development has been revealed. Serum ferritin levels and abnormalities of iron transport proteins, transferrin and their receptors can be used as prognostic indicators for lymphohematopoietic tumours and have opened up new directions of diagnosis and treatment, with a large number of novel drugs targeting tumours emerging to date. This article briefly describes the normal iron metabolism process and highlights the progress of research on abnormal iron metabolism in lymphohematopoietic tumors at the systemic and cellular levels.
