A Prognostic Nomogram Based on Response to Bortezomib and BTK Expression for Treatment-Experienced Multiple Myeloma Patients.
10.19746/j.cnki.issn.1009-2137.2022.04.025
- Author:
Hui-Ling CHEN
1
;
Cheng-Cheng MA
1
;
Ye CHAI
1
;
Peng-Yun ZENG
1
;
Chong-Yang WU
1
;
Ling-Ling YUE
1
;
Ti-Yun HAN
2
;
De-Kui ZHANG
3
Author Information
1. Department of Hematology,Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
2. Department of Gastroenterology,Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
3. Department of Gastroenterology,Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China .E-mail: sczdk1972@163.com.
- Publication Type:Journal Article
- Keywords:
BTK;
Oncomine database;
clinical predictive model;
multiple myeloma;
nomogram
- MeSH:
Bortezomib/therapeutic use*;
Humans;
Multiple Myeloma/drug therapy*;
Nomograms;
Prognosis;
Proportional Hazards Models
- From:
Journal of Experimental Hematology
2022;30(4):1139-1143
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a prognostic nomogram based on response to bortezomib and BTK expression for treatment-experienced multiple myeloma patients.
METHODS:The Oncomine database was utilized to determine BTK expression, sex, age, albumin, Mayo index, response to bortezomib treatment, follow-up time and survival status in multiple myeloma(MM) patients. Cut-off point for BTK expression was calculated using R software. Univariate and multivariate analyses by Cox proportional hazards regression were then performed. Significant prognostic factors were combined to build a nomogram. The discrimination ability and predictive accuracy of the nomogram were evaluated using the index of concordance (C-index) and calibration curves.
RESULTS:Multivariate analysis showed that response to bortezomib, BTK expression and sex were independent risk factors for prognosis. The C-index value of the nomogram made according to the independent risk factors was 0.729 (95%CI, 0.642-0.8164). The calibration curves showed good consistency between predicted and actual survivals for 1-year and 2-year overall survival.
CONCLUSION:The proposed nomogram is accurate in predicting the prognosis of patients with MM.
