Correlation between Peripheral Blood Intermediate Monocytes Increased and the Disease Progression of Patients with Diffuse Large BCell Lymphoma.
10.19746/j.cnki.issn.1009-2137.2022.04.021
- Author:
Quan Quan HU
1
;
Hui Ping WANG
2
;
Kang Sheng GU
3
;
Zhi Min ZHAI
2
;
Yan Li LI
4
Author Information
1. Department of Pathology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China.
2. Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.
3. Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
4. Department of Pathology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China,Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China,Email: liyanli_rainbow126@163.com.
- Publication Type:Journal Article
- Keywords:
diagnostic index;
diffuse large Bcell lymphoma;
disease progression;
flow cytometry;
intermediate monocytes
- MeSH:
Antineoplastic Combined Chemotherapy Protocols;
Disease Progression;
Humans;
Lymphoma, Large B-Cell, Diffuse/drug therapy*;
Monocytes/pathology*;
Neoplasm Recurrence, Local/pathology*;
Prognosis;
Retrospective Studies
- From:
Journal of Experimental Hematology
2022;30(4):1116-1122
- CountryChina
- Language:Chinese
-
Abstract:
UNLABELLED:AbstractObjective: To explore the distribution characteristics and clinical significance of peripheral blood monocyte subgroups in patients with diffuse large Bcell lymphoma(DLBCL).
METHODS:The percentage of peripheral blood monocyte subsets of 82 DLBCL patients (including 32 newly diagnosis, 29 remission and 21 relapse) and 30 healthy controls were detected by flow cytometry, and the correlation with the clinical characteristics and its diagnostic value of DLBCL were analyzed.
RESULTS:The proportion of intermediate monocytes in patients with newly diagnosed DLBCL group was higher than that in healthy controls (t=5.888, P<0.01). The proportion in relapsed group was higher than those in newly diagnosed DLBCL group（t=2.106，P=0.04） and remission group （t=6.882， P＜0.01）, and the proportion of intermediate monocytes in newly diagnosed DLBCL group was higher than that in Remission group (t=3.969, P<0.01). With the increase of International Prognostic Index (IPI) score, the percentage of intermediate monocytes in patients with DLBCL increased (r=0.37). Furthermore, when the proportion of intermediate monocytes was 10.91% as the cutoff value, the sensitivity and specificity of the whole sample were 90.60% and 9100%, respectively.
CONCLUSION:The disease progression is related to the increased intermediate monocytes, which can be used as a potential diagnostic index for DLBCL.
