Prevalence and risk factors of obesity in children with Diamond-Blackfan anemia.
10.7499/j.issn.1008-8830.2206070
- Author:
Mei-Hui YI
1
;
Yang WAN
1
;
Si-Qi CHENG
;
Xiao-Wen GONG
1
;
Zi-Xi YIN
1
;
Jun LI
1
;
Yang-Yang GAO
1
;
Chao WU
1
;
Su-Yu ZONG
1
;
Li-Xian CHANG
1
;
Yu-Mei CHEN
1
;
Rong-Xiu ZHENG
;
Xiao-Fan ZHU
1
Author Information
1. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
- Publication Type:Journal Article
- Keywords:
Body mass index;
Child;
Diamond-Blackfan anemia;
Obesity;
Ribosomal protein gene
- MeSH:
Child;
Male;
Female;
Humans;
Anemia, Diamond-Blackfan/genetics*;
Pediatric Obesity/complications*;
Glucocorticoids/therapeutic use*;
Prevalence;
Risk Factors;
Ribosomal Proteins/genetics*;
Mutation
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(10):1143-1148
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the distribution of body mass index (BMI) and risk factors for obesity in children with Diamond-Blackfan Anemia (DBA).
METHODS:The children with DBA who attended National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, from January 2003 to December 2020 were enrolled as subjects. The related clinical data and treatment regimens were recorded. The height and weight data measured within 1 week before or after follow-up time points were collected to calculate BMI. The risk factors for obesity were determined by multivariate regression analysis in children with DBA.
RESULTS:A total of 129 children with DBA were enrolled, among whom there were 80 boys (62.0%) and 49 girls (38.0%), with a median age of 49 months (range 3-189 months). The prevalence rate of obesity was 14.7% (19/129). The multivariate logistic regression analysis showed that the absence of ribosomal protein gene mutation was closely associated with obesity in children with DBA (adjusted OR=3.63, 95%CI: 1.16-11.38, adjusted P=0.027). In children with glucocorticoid-dependent DBA, obesity was not associated with age of initiation of glucocorticoid therapy, duration of glucocorticoid therapy, and maintenance dose of glucocorticoids (P>0.05).
CONCLUSIONS:There is a high prevalence rate of obesity in children with DBA, and the absence of ribosomal protein gene mutation is closely associated with obesity in children with DBA.
