Risk factors for acute kidney injury after hematopoietic stem cell transplantation in children: a retrospective study.
10.7499/j.issn.1008-8830.2205007
- Author:
Jian LIU
1
;
Zhi-Wei CHEN
1
;
Ying-Jie WANG
1
;
Yu-Miao MAI
1
;
Hui-Hui HU
1
;
Bing REN
1
;
Ying-Chao WANG
1
;
Yu-Feng LIU
1
Author Information
1. Department of Pediatrics, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
- Publication Type:Journal Article
- Keywords:
Acute kidney injury;
Child;
Hematopoietic stem cell transplantation;
Risk factor
- MeSH:
Child;
Humans;
Retrospective Studies;
Hematopoietic Stem Cell Transplantation/adverse effects*;
Graft vs Host Disease/complications*;
Risk Factors;
Acute Kidney Injury/therapy*;
Thrombotic Microangiopathies/complications*
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(10):1136-1142
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the risk factors for acute kidney injury (AKI) after hematopoietic stem cell transplantation (HSCT) in children.
METHODS:A retrospective analysis was performed on the medical data of 111 children who underwent HSCT from January 2018 to January 2020. A multivariate logistic regression analysis was used to identify the risk factors for AKI. The Kaplan-Meier survival analysis was used to compare the prognosis in children with different grades of AKI.
RESULTS:Graft-versus-host disease (grade Ⅱ-Ⅳ) (OR=4.406, 95%CI: 1.501-12.933, P=0.007), hepatic veno-occlusive disease (OR=4.190, 95%CI: 1.191-14.740, P=0.026), and thrombotic microangiopathy (OR=10.441, 95%CI: 1.148-94.995, P=0.037) were closely associated with the development of AKI after HSCT. The children with stage Ⅲ AKI had a lower 1-year survival rate than those without AKI or with stage Ⅰ AKI or stage Ⅱ AKI (28.6%±12.1% vs 82.8%±5.2%/81.7%±7.4%/68.8%±11.6%; P<0.05).
CONCLUSIONS:Children with stage Ⅲ AKI after HSCT have a higher mortality rate. Graft-versus-host disease, hepatic veno-occlusive disease, and thrombotic microangiopathy are closely associated with the development of AKI after HSCT.
