Clinical features of children and their family members with family clusters of SARS-CoV-2 Omicron variant infection in Shanghai, China: an analysis of 380 cases.
10.7499/j.issn.1008-8830.2205179
- Author:
Xiang-Li BIAN
1
;
Zhi GUO
1
;
Kun ZHANG
1
;
Miao-Chen LI
1
;
Zhi-Min WU
1
;
Qin JIANG
1
;
Miao-Miao GUO
1
;
Sai-Nan FAN
1
;
Juan-Juan CHEN
1
;
Lei HUI
1
;
Fang ZHENG
1
;
Jin-Ping ZHANG
1
Author Information
1. Department of Pediatrics, Shanghai Sixth People's Hospital, Shanghai 201306, China.
- Publication Type:Journal Article
- Keywords:
Child;
Clinical feature;
Coronavirus disease 2019;
Family cluster infection;
Omicron variant
- MeSH:
Adult;
Humans;
COVID-19/epidemiology*;
SARS-CoV-2;
Cough;
Retrospective Studies;
COVID-19 Vaccines;
China/epidemiology*;
Family;
Nucleic Acids
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(10):1085-1091
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To study the clinical features and prognosis of children and their family members with family clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infection under the admission mode of parent-child ward.
METHODS:A retrospective analysis was performed on the medical data of 190 children and 190 family members with SARS-CoV-2 Omicron variant infection who were admitted to Shanghai Sixth People's Hospital, the designated hospital for coronavirus disease 2019 (COVID-19), April 8 to May 10, 2022.
RESULTS:Both the child and adult groups were mainly mild COVID-19, and the proportion of mild cases in the child group was higher than that in the adult group (P<0.05). Respiratory symptoms were the main clinical manifestations in both groups. Compared with the adult group, the child group had higher incidence rates of fever, abdominal pain, diarrhea, and wheezing (P<0.05) and lower incidence rates of nasal obstruction, runny nose, cough, dry throat, throat itching, and throat pain (P<0.05). Compared with the child group, the adult group had higher rates of use of Chinese patent drugs, traditional Chinese medicine decoction, recombinant interferon spray, cough-relieving and phlegm-eliminating drugs, and nirmatrelvir/ritonavir tablets (P<0.05). Compared with the adult group, the child group had a lower vaccination rate of SARS-CoV-2 vaccine (30.5% vs 71.1%, P<0.001) and a shorter duration of positive SARS-CoV-2 nucleic acid (P<0.05). The patients with mild COVID-19 had a shorter duration of positive SARS-CoV-2 nucleic acid than those with common COVID-19 in both groups (P<0.05). The patients with underlying diseases had a longer duration of positive SARS-CoV-2 nucleic acid than those without such diseases in both groups (P<0.05).
CONCLUSIONS:Both children and adults with family clusters of SARS-CoV-2 Omicron variant infection manifest mainly mild COVID-19. Despite lower vaccination rate of SARS-CoV-2 vaccine in children, they have rapid disease recovery, with a shorter duration of positive SARS-CoV-2 nucleic acid than adults, under the admission mode of parent-child ward.
