Recent research on the association between signal transducer and activator of transcription 5 and childhood acute lymphoblastic leukemia.
10.7499/j.issn.1008-8830.2203117
- Author:
Yi-Fei DUAN
1
;
Fei-Qiu WEN
1
Author Information
1. Department of Pediatric Hematology and Oncology, Shenzhen Children's Hospital, China Medical University, Shenzhen, Guangdong 518000, China.
- Publication Type:Review
- Keywords:
Acute lymphoblastic leukemia;
Child;
Signal transducer and activator of transcription 5;
Signal transduction
- MeSH:
Apoptosis;
Cell Proliferation;
Child;
Humans;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
STAT5 Transcription Factor;
Signal Transduction
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(8):942-947
- CountryChina
- Language:English
-
Abstract:
Signal transducer and activator of transcription 5 (STAT5) can be involved in the processes such as cell proliferation, differentiation, apoptosis, and hematopoiesis, and its dysregulation is closely associated with the development and progression of malignant tumors including leukemia and may affect the treatment outcome and prognosis of pediatric patients. Identification of STAT5 can facilitate targeted therapy to improve the response rate of children with acute lymphoblastic leukemia. This article reviews the impact of STAT5 on the development/progression, targeted therapy strategies and the prognosis of childhood acute lymphoblastic leukemia.
