Risk factors for necrotizing enterocolitis in preterm infants: a Meta analysis.
10.7499/j.issn.1008-8830.2202085
- Author:
Chun-Yun LU
1
;
Ke-Feng LIU
1
;
Gao-Xing QIAO
1
;
Yuan LUO
;
Hui-Qing CHENG
;
Shu-Zhang DU
1
Author Information
1. Department of Pharmacy, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
- Publication Type:Meta-Analysis
- Keywords:
Meta analysis;
Necrotizing enterocolitis;
Preterm infant;
Risk factor
- MeSH:
Anti-Bacterial Agents;
Asphyxia;
Cesarean Section;
Cholestasis, Intrahepatic;
Diabetes, Gestational;
Ductus Arteriosus, Patent;
Enterocolitis, Necrotizing;
Female;
Humans;
Infant;
Infant, Newborn;
Infant, Newborn, Diseases;
Infant, Premature;
Pre-Eclampsia;
Pregnancy;
Pulmonary Surfactants;
Risk Factors;
Sepsis
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(8):908-916
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To systematically evaluate the risk factors for necrotizing enterocolitis (NEC) in preterm infants.
METHODS:PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Data were searched for case-control studies and cohort studies on the risk factors for NEC in preterm infants published up to December 2021. RevMan 5.3 software was used to perform the Meta analysis.
RESULTS:A total of 38 studies were included (28 case-control studies and 10 cohort studies). The Meta analysis showed that maternal gestational diabetes (OR=2.96, P<0.001), intrahepatic cholestasis during pregnancy (OR=2.53, P<0.001), preeclampsia (OR=1.73, P=0.020), history of neonatal asphyxia (OR=2.13, P<0.001), low gestational age (OR=1.23, P=0.010), sepsis (OR=5.32, P<0.001), patent ductus arteriosus (OR=1.57, P=0.001), congenital heart disease (OR=3.78, P<0.001), mechanical ventilation (OR=2.23, P=0.020), history of antibiotic use (OR=1.07, P<0.001), use of vasopressors (OR=2.34, P=0.040), and fasting (OR=1.08, P<0.001) were risk factors for NEC in preterm infants, while cesarean section (OR=0.73, P=0.004), use of pulmonary surfactant (OR=0.43, P=0.008), and breastfeeding (OR=0.24, P=0.020) were protective factors against NEC.
CONCLUSIONS:Maternal gestational diabetes, intrahepatic cholestasis during pregnancy, preeclampsia, low gestational age, fasting, sepsis, patent ductus arteriosus, congenital heart disease, and histories of asphyxia, mechanical ventilation, antibiotic use, and use of vasopressors may increase the risk of NEC in preterm infants, while cesarean section, use of pulmonary surfactant, and breastfeeding may decrease the risk of NEC in preterm infants.
