Influence of gender of reciprocal translocation carriers on the occurrence of embryonic chromosomal abnormalities.
10.3760/cma.j.cn511374-20210907-00728
- Author:
Jun WANG
1
;
Xiyi WANG
;
Xingqing GOU
;
Ying JU
;
Hengde ZHANG
;
Xiaohong WANG
Author Information
1. Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Tang Du Hospital, the Air Force Military Medical University, Xi'an, Shaanxi 710038, China. wangxh99919@126.com.
- Publication Type:Journal Article
- MeSH:
Adult;
Blastocyst;
Chromosome Aberrations;
Female;
Genetic Testing/methods*;
Humans;
Male;
Pregnancy;
Preimplantation Diagnosis/methods*;
Retrospective Studies;
Translocation, Genetic
- From:
Chinese Journal of Medical Genetics
2022;39(9):958-962
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the influence of gender of chromosomal translocation carriers on the occurrence of embryonic chromosomal aberrations.
METHODS:A retrospective study was carried out. Data were collected from 235 couples carrying reciprocal translocations (1163 blastocysts) and 70 couples carrying Robertsonian translocations (351 blastocysts). The preimplantation genetic testing for structural rearrangement (PGT-SR) analysis of 1514 blastocysts were completed through next generation sequencing (NGS).
RESULTS:After adjusting the confounding factors such as female age, AMH, ovarian stimulation regimen, and Gn dosage, the results showed that the risk for blastocyst chromosomal abnormalities was 0.41 [OR(95%CI), 1.41(1.06, 1.87), P < 0.05] times higher in female reciprocal translocation carriers and 1.02 [OR(95%CI), 2.02 (1.20, 3.40), P < 0.01] times higher in female Robertsonian translocation carriers compared with male carriers, respectively. Compared with male carriers, the risk of blastocyst chromosomal abnormalities was increased by 0.67 times [OR(95%CI), 1.67 (1.10, 2.56), P < 0.05] in female reciprocal translocation carriers over 30 years old and 1.06 times [OR(95%CI), 2.06 (1.02, 4.15), P = 0.0434, P < 0.05] in female Robertsonian translocation carriers between 25 and 30 years old.
CONCLUSION:Compared with male carriers, female carriers of reciprocal or Robertsonian translocations have a higher risk for producing embryos with chromosomal abnormalities, and their age may also be a risk factor.
