Study on the changes of cartilage metabolites in patients with knee osteoarthritis before and after fibula osteotomy.
10.12200/j.issn.1003-0034.2022.09.008
- Author:
Bi CHENG
1
;
Jin-Wei HE
1
;
Meng-Yao JIANG
1
Author Information
1. Department of Orthopaedics, Wuzhou Red Cross Hospital, Wuzhou 543002, Guangxi, China.
- Publication Type:Journal Article
- Keywords:
Cartilage;
Interleukin-1 β;
Osteoarthritis, knee;
Ostrotomy
- MeSH:
Adult;
Aged;
Cartilage, Articular/surgery*;
Collagen Type II;
Female;
Fibula/surgery*;
Humans;
Interleukin-1beta;
Male;
Middle Aged;
Osteoarthritis, Knee/surgery*;
Osteotomy;
Pain;
Tumor Necrosis Factor-alpha
- From:
China Journal of Orthopaedics and Traumatology
2022;35(9):843-847
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore changes of C-terminal cleavage epitope of type Ⅱ collagen 3/4 fragment in cartilage metabolism (Col2-3/4Clong mono or C2C), carboxyl-terminal telopeptide of type Ⅱ collagen (CTX-Ⅱ) and knee joint function before and after osteotomy of fibula in patients with knee osteoarthritis.
METHODS:From January 2019 to March 2020, 65 patients with knee osteoarthritis who underwent fibular osteotomy treatment accompanied with medial pain were selected, including 25 males and 40 females, aged from 44 to 70 years old with an average of (56.20±10.05) years old;25 patients were gradeⅠ, 19 patients with gradeⅡ, 17 patients with grade Ⅲ, and 4 patients with grade Ⅳ according to Kellgren-Lawrence grading. The content of CTX-Ⅱ and C2C in knee joint fluid, serum interleukin 1β ( IL-1β), tumor necrosis factor-α (TNF-α) before osteotomy and 6 months after osteotomy were detected. Visual analogue scale(VAS) was used to evaluate degree of pain relief, American Knee Society Score (KSS) and Hospital for Special Surgery (HSS) were applied to evaluate recovery of knee joint function.
RESULTS:Sixty-five patients were followed up from 6 to 18 months with an average of(12.4±3.6) months. VAS, KSS and HSS score at 6 months after osteotomy were better than that of before osteotomy(P<0.05). Serum IL-1β, TNF-α and content of CTX-Ⅱand C2C of knee joint fluid at 6 months after osteotomy were lower than those before osteotomy(P<0.05).
CONCLUSION:Fibula osteotomy could relieve pain of knee osteoarthritis, maintain balance of joint stress, reduce organism inflammatory response, improve cartilage metabolism, reduce decomposition of articular cartilage, and reduce level of CTX-Ⅱand C2C, which is benefit for regeneration of articular cartilage and promote recovery of knee joint function.
