Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease.

Na-na Zhang; Zi-jian LI; Hai-bo Zhu

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Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease.

Author: Na-Na ZHANG ¹ ; Zi-Jian LI ² ; Hai-Bo ZHU ³
Author Information

1. Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100050, China.
2. Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100050, China.
3. State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Publication Type:Journal Article
Keywords: coronary artery disease; higenamine; myocardial perfusion imaging; stress agent
MeSH: Humans; Coronary Artery Disease; Myocardial Perfusion Imaging/methods*; Tetrahydroisoquinolines; Alkaloids; Coronary Angiography/methods*
From: Chinese Medical Sciences Journal 2022;37(3):275-281
CountryChina
Language:English
Abstract: Myocardial perfusion imaging (MPI) is valuable for the diagnosis, prognosis, and management of coronary artery disease (CAD). The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic agents. However, these agents have contraindications and may cause adverse effects in some patients. Thus, other stress agents feasible for more patients are required. Higenamine (HG) is a β-adrenergic receptor agonist currently approved for clinical trials as a stress agent for myocardial infarction. It also has a promising value in MPI for the detection of CAD in preclinical and clinical studies. This review summarizes the application of HG on MPI, including its mechanism of action, stress protocol, efficacy, and safety.