Research progress on the fluorescence resonance energy transfer-based polymer micelles as drug carriers.
10.7507/1001-5515.202111040
- Author:
Linrui JIANG
1
;
Ni ZENG
1
;
Qingshan MIAO
1
;
Changqiang WU
2
;
Shaoyun SHAN
1
;
Hongying SU
1
Author Information
1. Department of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500, P. R. China.
2. Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China.
- Publication Type:Journal Article
- Keywords:
Drug carrier;
Fluorescence resonance energy transfer;
Fluorescent probe pairs;
Polymer micelles
- MeSH:
Micelles;
Drug Carriers/chemistry*;
Polymers/chemistry*;
Fluorescence Resonance Energy Transfer;
Polyethylene Glycols/chemistry*
- From:
Journal of Biomedical Engineering
2022;39(5):1022-1032
- CountryChina
- Language:Chinese
-
Abstract:
Polymer micelles formed by self-assembly of amphiphilic polymers are widely used in drug delivery, gene delivery and biosensors, due to their special hydrophobic core/hydrophilic shell structure and nanoscale. However, the structural stability of polymer micelles can be affected strongly by environmental factors, such as temperature, pH, shear force in the blood and interaction with non-target cells, leading to degradations and drug leakage as drug carriers. Therefore, researches on the structural integrity and in vivo distribution of micelle-based carriers are very important for evaluating their therapeutic effect and clinical feasibility. At present, fluorescence resonance energy transfer (FRET) technology has been widely used in real-time monitoring of aggregation, dissociation and distribution of polymer micelles ( in vitro and in vivo). In this review, the polymer micelles, characteristics of FRET technology, structure and properties of the FRET-polymer micelles are briefly introduced. Then, methods and mechanism for combinations of several commonly used fluorescent probes into polymer micelles structures, and progresses on the stability and distribution studies of FRET-polymer micelles ( in vitro and in vivo) as drug carriers are reviewed, and current challenges of FRET technology and future directions are discussed.
