Quantitative identification of Q-markers of Euphorbiae Humifusae Herba based on AHP-CRITIC comprehensive weighting method.
10.19540/j.cnki.cjcmm.20220511.202
- Author:
Xiao-Tao ZENG
1
;
Yan-Yan CHEN
2
;
Shi-Jun YUE
1
;
Ding-Qiao XU
1
;
Rui-Jia FU
1
;
Yu-Ping TANG
1
Author Information
1. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine Xi'an 712046, China.
2. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine Xi'an 712046, China Institute of Integrated Traditional and Western Medicine, Affiliated Hospital of Jiangnan University Wuxi 214062, China.
- Publication Type:Journal Article
- Keywords:
AHP-CRITIC comprehensive weighting method;
Euphorbiae Humifusae Herba;
quality markers(Q-markers);
quantitative identification
- MeSH:
Chromatography, High Pressure Liquid/methods*;
Quercetin;
Apigenin;
Quality Control;
Glucosides;
Drugs, Chinese Herbal/chemistry*
- From:
China Journal of Chinese Materia Medica
2022;47(19):5193-5202
- CountryChina
- Language:Chinese
-
Abstract:
This study investigated the quality markers(Q-markers) of Euphorbiae Humifusae Herba based on the analytic hierarchy process(AHP)-criteria importance through intercriteria correlation(CRITIC) comprehensive weighting method. The Q-markers evaluation system was constructed based on the AHP-CRITIC comprehensive weighting method with quantitative identification of Q-markers of Euphorbiae Humifusae Herba as the target layer. The index weights of the factor layer and the control layer were integrated based on the weights of three indicators(effectiveness, testability, and specificity) in the factor layer calculated by the AHP method and weights of eight indicators(anti-inflammatory inhibitory rate, coagulation shortening rate, anti-cancer inhibition rate, component degree value, component test batch, component average content, content variation coefficient, and number of medicinal materials retrieved according to components) in the control layer calculated by the CRITIC method. The comprehensive score of the chemical components of Euphorbiae Humifusae Herba was weighted and ranked to identify the Q-markers of Euphorbiae Humifusae Herba. In terms of comprehensive scores, top 10 potential Q-markers of Euphorbiae Humifusae Herba were ranked as cynaroside > quercetin > gallic acid > apigenin > luteolin > apigenin-7-O-glucoside > quercetin-7-O-glucoside > ellagic acid > astragalin > ethyl gallate. This study provides a reference for the quality control of Euphorbiae Humifusae Herba and a methodological reference for the quantitative identification of Q-markers of Chinese medicine.
