Research progress of Shenling Baizhu San and predictive analysis on its quality markers.
10.19540/j.cnki.cjcmm.20220421.201
- Author:
Guang-Ying LU
1
;
Xun-Yan XING
2
;
Jia-Yun WANG
3
;
Yuan WANG
1
;
Ke MA
1
;
Shi-Jun WANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine Ji'nan 250355, China Shandong Co-Innovation Center of Classic Traditional Chinese Medicine Formula Ji'nan 250355, China.
2. Affiliated Hospital of Shandong University of Traditional Chinese Medicine Ji'nan 250014, China.
3. Shandong University of Traditional Chinese Medicine Ji'nan 250355, China.
- Publication Type:Journal Article
- Keywords:
Shenling Baizhu San;
chemical constituent;
clinical application;
pharmacological effect;
quality marker
- MeSH:
Humans;
Ginsenosides/therapeutic use*;
Drugs, Chinese Herbal/pharmacology*;
Colitis, Ulcerative/drug therapy*;
Diarrhea/drug therapy*
- From:
China Journal of Chinese Materia Medica
2022;47(19):5171-5181
- CountryChina
- Language:Chinese
-
Abstract:
Shenling Baizhu San is a classic prescription for replenishing Qi to invigorate the spleen and dispelling dampness to check diarrhea, which mainly treats the syndrome of spleen deficiency and heavy dampness. With the pharmacological effects of regulating immune system, improving lung function and gastrointestinal function, and resisting oxygen, tumor, and inflammation, Shenling Baizhu San is commonly used in modern clinical practice to treat chronic obstructive pulmonary disease, pulmonary fibrosis, bronchial asthma, irritable bowel syndrome, ulcerative colitis, chronic diarrhea, and diabetic, etc. This paper summarized the chemical constituents, pharmacological effects, and clinical application of Shenling Baizhu San in recent years, and predictively analyzed the quality markers of Shenling Baizhu San according to the "five principles" of Q-marker. The Q-markers of Shenling Baizhu San involved ginsenoside Rg_1, ginsenoside Re, ginsenoside Rb_1, pachymic acid, dehydrotumulosic acid, batatasin Ⅰ, batatasin Ⅲ, diosgenin, liensinine, neferine, luteolin, quercetin, glycerol trioleate, β-sitosterol, platycodin D, glycyrrhizic acid, glycyrrhetinic acid, liquiritin, pipecolinic acid, atractylenolide Ⅰ, atractylenolide Ⅲ, and bornyl acetate, which provided references for the quality control and follow-up research of Shenling Baizhu San.
