Prevention and treatment of non-alcoholic fatty liver disease by regulation of mitochondrial function with Chinese medicine.
10.19540/j.cnki.cjcmm.20220704.601
- Author:
Qiong MA
1
;
An-Hua SHI
1
;
Xi ZHAO
1
;
Wen-Ling CHEN
2
Author Information
1. Yunnan University of Chinese Medicine Kunming 650500, China Key Laboratory of Microcosmic Syndrome Differentiation Kunming 650500, China.
2. Yunnan University of Chinese Medicine Kunming 650500, China the First Clinical College of Yunnan University of Chinese Medicine Kunming 650500, China.
- Publication Type:Journal Article
- Keywords:
mechanism;
mitochondrial function;
non-alcoholic fatty liver disease(NAFLD);
traditional Chinese medicine
- MeSH:
Humans;
Non-alcoholic Fatty Liver Disease/metabolism*;
Medicine, Chinese Traditional/adverse effects*;
Liver;
Mitochondria/pathology*;
Lipid Metabolism
- From:
China Journal of Chinese Materia Medica
2022;47(19):5113-5120
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease(NAFLD), as a metabolic stress liver injury disease, is one of the most common chronic liver diseases, which seriously threatens people's health. The pathogenesis of NAFLD is very complex. A large number of studies show that the hepatic mitochondrial dysfunction leads to the disorder of hepatic glucose and lipid metabolism, oxidative stress, and inflammation, thus inducing hepatocyte apoptosis, which plays an important role in the progression of NAFLD. In recent years, researchers have begun to focus on developing drugs that slowed the progression of NAFLD by regulating the hepatic mitochondrial function. Chinese medicine has a good curative effect on the treatment of NAFLD, with the advantages of high safety and few side effects. Various studies have shown that Chinese medicine prevented and treated NAFLD by regulating the mitochondrial function. Therefore, this paper summarized the relationship between NAFLD and mitochondria, and the mechanism of Chinese medicine(single Chinese medicine, Chinese medicine monomer, and Chinese medicine compound prescription) in the prevention and treatment of NAFLD by regulating mitochondrial function. This paper is expected to provide references for clinical application of traditional Chinese medicine in the treatment of NAFLD by regulating mitochondrial function.
