A new xanthone from Hypericum lagarocladum.
10.19540/j.cnki.cjcmm.20220418.202
- Author:
Jing-Tong DENG
1
;
Tong-Xi ZHOU
2
;
Ying-Chun YANG
2
;
Qing-di HAN
1
;
Hai-Tao CHENG
1
;
Qiang WANG
1
;
Xin-Zhou YANG
1
Author Information
1. School of Pharmaceutical Sciences, South-Central Minzu University Wuhan 430074, China.
2. Yichang Academy of Agricultural Sciences Yichang 443000, China.
- Publication Type:Journal Article
- Keywords:
Hypericum lagarocladum;
chemical component;
glucose uptake;
xanthone
- MeSH:
Hypericum/chemistry*;
Xanthones;
Chromatography, High Pressure Liquid;
Magnetic Resonance Spectroscopy;
Glucose
- From:
China Journal of Chinese Materia Medica
2022;47(20):5544-5549
- CountryChina
- Language:Chinese
-
Abstract:
Repeated silica gel column chromatography, reversed-phase C_(18) column chromatography, Sephadex LH-20 column chromatography, high performance liquid chromatography and semi-preparative medium pressure liquid chromatography were performed to separate and purify the chemical constituents of Hypericum lagarocladum. Spectroscopic methods such as mass spectrometry(MS) and nuclear magnetic resonance(NMR) combined with physicochemical properties were adopted in identifying the structure of the isolated compounds. Ten compounds were isolated from the ethyl acetate fraction of H. lagarocladum and identified as lagarxanthone A(1), 1,7-dihydroxyxanthone(2), 3,4,5-trihydroxyxanthone(3), 2,7-dihydroxy-1-methoxyxanthone(4), 1,3-dihydroxy-7-methoxyxanthone(5), 1,5-dihydroxy-8-methoxyxanthone(6), 3,4-dihydroxy-2-methoxyxanthone(7), 3,4-dihydroxy-5-methoxyxanthone(8), 2,3-dimethoxyxanthone(9), and 2,3,4-trimethoxyxanthone(10). Among them, compound 1 was a new compound, and compounds 2-10 were isolated from this plant for the first time. These ten compounds were tested for glucose uptake in L6 cells, and the results showed that all the compounds had no significant effect on glucose uptake.
