A new sesquiterpene from stems of Buddleja lindleyana.
10.19540/j.cnki.cjcmm.20220412.203
- Author:
Zhao-Chan CHEN
1
;
Yun-Shuang CAI
1
;
Shi-Shan YU
2
Author Information
1. Guangxi University of Chinese Medicine Nanning 530200, China.
2. Guangxi University of Chinese Medicine Nanning 530200, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Buddleja lindleyana;
chemical constituent;
sesquiterpene
- MeSH:
Buddleja/chemistry*;
Sesquiterpenes/pharmacology*;
Chromatography, High Pressure Liquid
- From:
China Journal of Chinese Materia Medica
2022;47(20):5537-5543
- CountryChina
- Language:Chinese
-
Abstract:
The present study investigated the chemical constituents from the stems of Buddleja lindleyana. Ten compounds were isolated from the 95% EtOH extract of B. lindleyana stems by means of some techniques including polyamide, silica gel, MCI, Sephadex LH-20 column chromatography, and semi-preparative high-performance liquid chromatography(HPLC). Their structures were identified by spectral analysis and single-crystal X-ray diffraction as buddledin F(1), 6-O-4″-hydroxy-3″-methoxy-benzoyl ajugol(2), negundoin G(3),(+)-dihydrocubebin(4), 7-O-ethylguaiacylglycerol(5),(-)-jatrointelignan B(6), threo-1,2-bis-(4-hydroxy-3-methoxyphenyl)-propane-1,3-diol(7), vomifoliol(8), hinokinin(9), and isovanillic acid(10). Compound 1 was a new sesquiterpene named buddledin F. Compounds 3-8 were isolated from the Buddleja plant for the first time. The anti-inflammatory activities of compounds 1-10 in vitro were investigated, and the results failed to show the inhibitory activities of these compounds on the production of inflammatory factor NO.
