Common anti-inflammatory effects of heat-clearing and toxin-removing Chinese medicines on diverse cardiovascular diseases.
10.19540/j.cnki.cjcmm.20220601.701
- Author:
Dong WANG
1
;
Xue YU
1
;
Kai HUANG
1
;
Jia-Yang TANG
1
;
Xiao-Qi WEI
1
;
Hai-Yin PU
1
;
Shu-Zhen GUO
1
Author Information
1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
cardiovascular diseases;
clearing heat and removing toxin;
inflammation;
same treatment method for different diseases
- MeSH:
Humans;
Cardiovascular Diseases/drug therapy*;
Hot Temperature;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/pharmacology*;
Inflammation/drug therapy*;
China;
Anti-Inflammatory Agents/therapeutic use*
- From:
China Journal of Chinese Materia Medica
2022;47(20):5418-5423
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases seriously affect human health and their prevalence continues to increase with the aging of the population. The integrated therapy of traditional Chinese medicine(TCM) and western medicine for cardiovascular diseases has achieved certain results, but it is still faced with new challenges. Studies have shown that inflammation plays an important role in the development of cardiovascular diseases and some of these mechanisms have common features. For example, in cardiovascular diseases, C-C motif chemokine receptor 2(CCR2)-expressing macrophages increase and promote inflammation, and excessive activation of NOD-like receptor protein 3(NLRP3) inflammasome leads to the elevation of inflammatory factors. There is also new understanding of the pathogenesis and treatment of cardiovascular diseases in TCM. The heat-toxicity theory in cardiovascular diseases and the therapeutic principle of clearing heat and removing toxin have attracted attention. The clinical and pharmacological studies on the treatment of cardiovascular diseases such as Huanglian Jiedu Decoction and Simiao Yong'an Decoction are also gradually increasing. The present study analyzed the common features of the inflammatory response mechanisms in diverse cardiovascular diseases and discussed the significance of the prevention and treatment of diverse cardiovascular diseases by the treatment method of clearing heat and removing toxin to regulate inflammation, which is expected to provide new ideas and references for clinical treatment and drug research on cardiovascular diseases with the same treatment method for different diseases.
