Role of SIRTs in cerebral ischemia reperfusion injury and targeted intervention of Chinese medicine.
10.19540/j.cnki.cjcmm.20220706.601
- Author:
Guang-Shan HUANG
1
;
Xuan WEI
1
;
Kai YANG
1
;
Ji-Yong LIU
2
;
Jin-Wen GE
3
;
Zhi-Gang MEI
4
Author Information
1. Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine Changsha 410208, China.
2. Hunan Provincial Key Laboratory of Diagnostic Research in Chinese Medicine, Hunan University of Chinese Medicine Changsha 410208, China.
3. Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine Changsha 410208, China Hunan Academy of Chinese Medicine Changsha 410006, China.
4. Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine Changsha 410208, China Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by National Administration of Traditional Chinese Medicine, Medical College of China Three Gorges University Yichang 443002, China.
- Publication Type:Journal Article
- Keywords:
cerebral ischemia-reperfusion injury;
review;
silent information regulators(SIRTs);
stroke
- MeSH:
Humans;
Brain Ischemia/therapy*;
Ischemic Stroke/therapy*;
Medicine, Chinese Traditional;
Oxidative Stress;
Reperfusion Injury/therapy*;
Sirtuins/metabolism*
- From:
China Journal of Chinese Materia Medica
2022;47(20):5406-5417
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia-reperfusion injury(CIRI) is a complex cascade process and seriously hinders the recovery of patients with acute ischemic stroke, which has become an urgent public health issue to be addressed. Silent information regulators(SIRTs) are a family of nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, capable of deacylating the histone and non-histone lysine groups. Accumulating evidence has demonstrated that SIRTs are able to regulate the pathological processes such as oxidative stress, inflammatory response, mitochondrial dysfunction, and programmed cell death of CIRI through post-translational deacetylation, and exert the neuroprotection function. In this study, we reviewed the papers about the role and regulatory mechanisms of SIRTs in the pathological process of CIRI published in the past decade. Further, we summarized the research advance in the prevention and treatment of CIRI with Chinese medicine targeting SIRTs and the related signaling pathways. This review will provide new targets and theoretical support for the clinical application of Chinese medicine in treating CIRI during the occurrence of ischemic stroke.
