Research progress on chemical constituents,pharmacological activities,and quality control of Patrinia villosa.
10.19540/j.cnki.cjcmm.20220323.201
- Author:
Yu FAN
1
;
Dong-Mei SHA
2
;
Ma-Li-Niu SHA
2
;
Jian-Long LAN
2
;
Lai-Yue-Bu HAI
2
;
Bie-Jun-Zhang QU
2
;
Xin-Jia YAN
2
;
Yuan LIU
2
Author Information
1. Institute of Qinghai-Tibetan Plateau,Southwest Minzu University Chengdu 610041,China Institute of Pharmaceutical Analysis,College of Pharmacy,Jinan University Guangzhou 510632,China.
2. Institute of Qinghai-Tibetan Plateau,Southwest Minzu University Chengdu 610041,China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225,China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology Engineering Laboratory Chengdu 610225,China.
- Publication Type:Journal Article
- Keywords:
Patrinia villosa;
chemical constituents;
pharmacological activity;
quality control
- MeSH:
Patrinia/chemistry*;
Flavonoids/pharmacology*;
Saponins;
Triterpenes/pharmacology*;
Iridoids;
Quality Control
- From:
China Journal of Chinese Materia Medica
2022;47(22):6005-6019
- CountryChina
- Language:Chinese
-
Abstract:
Patrinia villosa, regarding its functions in clearing heat and detoxification and eliminating carbuncles and pus, is widely used as a traditional medicinal herb that contains rich nutrition and substances such as various amino acids, vitamins, and soluble su-gar, and it is also an edible wild herb in Chinese folk tradition for 2 000 years. In 1973, Japanese scholars firstly separated three iridoids from Japanese P. villosa, and by 2021, chemical components such as flavonoids, iridoids, organic acids, triterpenoids, phenylpropanoids, and steroids have been found, which have multiple pharmacological effects, including antioxidant, antitumor, anti-diarrhea, antibacterial, sedative, and liver protection capabilities. Studies indicate that flavonoids, saponins, phenylpropanoids, and triterpenoids in P. villosa are vital substances for its pharmacological activities. However, the quality of this medicinal material cannot be controlled due to the unclear records in ancient books in the past dynasties and different drug use habits in different places, and thus its circulation is chaotic. At present, researchers have used flavonoids, organic acids, phenylpropanoids, triterpenoid saponins, and other compounds to conduct studies in this regard. Therefore, on the basis of the existing literature resources, we comprehensively summarize the chemical constituents, pharmacological activities, and quality control of P. villosa to further provide a reference for the safety and effectiveness of clinical drug use and lay a foundation for the follow-up experimental research.
