Chinese medicinal formulae treat inflammatory bowel diseases through maintaining gut flora homeostasis.
10.19540/j.cnki.cjcmm.20220706.501
- Author:
Qi-Rui WANG
1
;
Jing SHAO
2
Author Information
1. College of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine Hefei 230000, China.
2. College of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine Hefei 230000, China Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Traditional Chinese Medicine Hefei 230000, China.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
dysbiosis;
gut flora;
inflammatory bowel disease;
syndrome
- MeSH:
Humans;
Gastrointestinal Microbiome;
Inflammatory Bowel Diseases/drug therapy*;
Dysbiosis/drug therapy*;
Colitis, Ulcerative/drug therapy*;
Bacteria/genetics*;
Homeostasis;
China
- From:
China Journal of Chinese Materia Medica
2022;47(22):5997-6004
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD) is a chronic and recurrent inflammatory disorder of the gut, including Crohn's disease(CD) and ulcerative colitis(UC). The occurrence and development of IBD involves multiple pathogenic factors, and the dybiosis of gut flora is recognized as an important pathogenic mechanism of IBD. Therefore, restoring and maintaining the balance of gut flora including bacteria and fungi has become an effective option for IBD treatment. Based on the theoretical basis of the interaction between gut flora and IBD, this paper followed the principle of clinical syndrome differentiation for IBD therapy by traditional Chinese medicine(TCM), and summarized several Chinese medicinal formulae commonly used in IBD patients with large intestine damp-heat syndrome, intermingled heat and cold syndrome, spleen deficiency and dampness accumulation syndrome, spleen and kidney yang deficiency syndrome, liver stagnation and spleen deficiency syndrome, and severe heat poisoning syndrome. The therapeutic and regulatory effects of Shaoyao Decoction, Qingchang Suppository, Wumei Pills, Banxia Xiexin Decoction, Shenling Baizhu Powder, Lizhong Decoction, Sishen Pills, Tongxie Yaofang, Baitouweng Decoction, Gegen Qinlian Decoction, and Houttuyniae Herba prescriptions on gut flora of IBD patients were emphasized as well as the mechanisms. This study found that Chinese medicinal formulae increased the abundance of Bacteroidetes, Bifidobacteria, Lactobacillus, and other beneficial bacteria producing short-chain fatty acids, and reduced the abundance of Enterobacteriaceae and other harmful bacteria to restore the balance of gut flora, thus treating IBD. Confronting the recalcitrance and high recurrence of IBD, Chinese medicinal formulae provide new opportunities for IBD treatment through intervening dysbiosis of gut flora.
