Overview of research and development of polypeptide drugs and traditional Chinese medicine-peptides.
10.19540/j.cnki.cjcmm.20220726.601
- Author:
Xiao-Nan YANG
1
;
Li-Jun RUAN
1
;
Xing JIANG
2
;
Zhi-Jun SONG
3
;
Kun-Hua WEI
1
;
Shuang-Shuang QIN
1
;
Ying LIANG
1
;
Xiao-Li HOU
1
;
Xi-Jun WANG
4
;
Jian-Hua MIAO
5
Author Information
1. Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement/Guangxi Engineering Research Center of TCM Resource Intelligent Creation,Guangxi Botanical Garden of Medicinal Plant Nanning 530023,China.
2. Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement/Guangxi Engineering Research Center of TCM Resource Intelligent Creation,Guangxi Botanical Garden of Medicinal Plant Nanning 530023,China the Second Affiliated Hospital of Hengyang Medical School,University of South China Hengyang 421001,China.
3. National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials,Guangxi Botanical Garden of Medicinal Plants Nanning 530023,China.
4. National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials,Guangxi Botanical Garden of Medicinal Plants Nanning 530023,China Engineering Research Center of Efficacy Evaluation and Industrial Development of TCM Classic Formulae of the Ministry of Education,Chinmedomics Research Center of National Administration of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine Harbin 150040,China.
5. Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement/Guangxi Engineering Research Center of TCM Resource Intelligent Creation,Guangxi Botanical Garden of Medicinal Plant Nanning 530023,China National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials,Guangxi Botanical Garden of Medicinal Plants Nanning 530023,China.
- Publication Type:Journal Article
- Keywords:
TCM-peptides;
bioactivity;
drug development;
research method
- MeSH:
Medicine, Chinese Traditional;
Artificial Intelligence;
Drugs, Chinese Herbal/chemistry*;
Research Design;
Peptides;
Proteins;
Amino Acids
- From:
China Journal of Chinese Materia Medica
2022;47(22):5978-5990
- CountryChina
- Language:Chinese
-
Abstract:
Peptide is a compound consisting of 2-50 amino acids, which is intermediate between small molecule and protein. It is characterized by a variety of biological activities, easy absorption, strong specific targeting, and few side effects and has become one of the hotspots in biomedical research in recent years. Chinese medicine contains a large number of peptides. The traditional processing methods such as decocting and boiling can effectively boost peptides to exert their due biological activities. At present, however, the research on Chinese medicinal components in laboratory generally employs high-concentration alcohol extraction method, which may cause the peptides to be ignored in many natural Chinese medicines. Substantial studies have revealed that the peptides in Chinese medicine are important material basis responsible for the traditional efficacy. Based on years of research and literature retrieval, this study put forward the concept of "traditional Chinese medicine(TCM)-peptides", referring to the components consisting of two or more amino acids with molecular weight between small molecules and proteins that can express the efficacy of Chinese medicine. Furthermore, this study also summarized the extraction and separation of TCM-peptides, and structure determination methods and routes, predicted the research prospect of modern research methods of TCM-peptides based on "holistic view" and big data. The artificial intelligence prediction was combined with high-throughput screening technology to improve the discovery efficiency and accuracy of TCM-peptides, and holographic images between TCM-peptides and biological targets were established to provide references for the innovative drug design and related health product development of TCM-peptides based on TCM theories.
