Research progress on liposome and nanomicelle targeted drug delivery system across blood-brain barrier.
10.19540/j.cnki.cjcmm.20220726.602
- Author:
Xu YANG
1
;
Ling-Hui ZOU
1
;
Wen-Ya DING
2
;
Zhong-Bin ZHANG
1
;
Jin-Qing CHEN
1
;
Ji-Lang LI
1
;
Hong-Li FENG
1
;
Yu-Yang LI
1
;
Ling TANG
1
;
Jian-Fang FENG
3
Author Information
1. College of Pharmacy, Guangxi University of Chinese Medicine Nanning 530299, China.
2. College of Pharmacy, Guangxi University of Chinese Medicine Nanning 530299, China Key Laboratory of Common Technology of Chinese Medicine Preparations in Guangxi Universities Nanning 530299, China.
3. College of Pharmacy, Guangxi University of Chinese Medicine Nanning 530299, China South China Branch of National Engineering Research Center for Manufacturing Technology of Traditional Chinese Medicine Solid Preparation Nanning 530299, China.
- Publication Type:Journal Article
- Keywords:
blood-brain barrier;
liposomes;
micelles;
targeted agents;
targeted groups;
targeted nano-drug delivery system
- MeSH:
Humans;
Blood-Brain Barrier;
Liposomes;
Micelles;
Drug Delivery Systems;
Biological Transport;
Brain;
Brain Diseases
- From:
China Journal of Chinese Materia Medica
2022;47(22):5965-5977
- CountryChina
- Language:Chinese
-
Abstract:
The blood-brain barrier(BBB), a protective barrier between brain tissues and brain capillaries, can prevent drugs from entering the brain tissues to exert the effect, which greatly increases the difficulty in treating brain diseases. The drug delivery system across the BBB can allow efficient drug delivery across the BBB by virtue of carriers and formulations, thereby enhancing the therapeutic effect of drugs on brain tissue diseases. Liposomes and micelles have been extensively studied with advances in the targeted therapy across the BBB for the brain due to their unique structures and drug delivery advantages. This study summarized the research status of liposome and micelle drug delivery systems across the BBB based on the literature in recent years and analyzed their application advantages and mechanism in terms of trans-BBB capability, targeting, and safety. Moreover, the problems and possible countermeasures in the research on trans-BBB liposomes and micelles were discussed according to the current clinical translation, which may provide refe-rences and ideas for the development of trans-BBB targeted nano-drugs.
