Systematic review and pharmacoeconomic evaluation of Qizhi Weitong Granules in treatment of functional dyspepsia.
10.19540/j.cnki.cjcmm.20220529.502
- Author:
Ke-Biao LI
1
;
Yang TIAN
1
;
Sheng HAN
2
;
Li-Kai LIN
1
;
Wei LI
2
Author Information
1. Hospital Management Institute of Wuhan University Wuhan 430071, China.
2. International Research Center for Medical Administration, Peking University Beijing 100191, China.
- Publication Type:Systematic Review
- Keywords:
Meta-analysis;
Qizhi Weitong Granules;
cost-effectiveness analysis;
decision tree model;
functional dyspepsia
- MeSH:
Benzamides;
Cost-Benefit Analysis;
Dyspepsia/drug therapy*;
Economics, Pharmaceutical;
Gastrointestinal Agents/therapeutic use*;
Humans;
Morpholines;
Treatment Outcome
- From:
China Journal of Chinese Materia Medica
2022;47(18):5106-5112
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to investigate the efficacy, safety, and cost-effecctiveness of Qizhi Weitong Granules in the treatment of functional dyspepsia. Specifically, two commonly used clinical protocols for the treatment of functional dyspepsia were selected: Qizhi Weitong Granules+Mosapride vs Mosapride alone(control). Meta-analysis of previous clinical studies was performed to examine the efficacy and safety, and pharmacoeconomic evaluation was carried out according to the results of the Meta-analysis. The cost-effectiveness analysis was carried out to elucidated the incremental cost-effectiveness ratio(ICER), and the sensitivity was analyzed with tornado dia-gram and Monte Carlo simulation. The willingness-to-pay threshold of patients for functional dyspepsia was investigated and compared with the ICER to evaluate whether Qizhi Weitong Granules was cost-effective. The result showed that the effective rate of Qizhi Weitong Granules combined with Mosapride in the treatment of functional dyspepsia was 95.49%, which was higher than that of Mosapride alone(73.30%)(OR=8.52, 95%CI[4.36, 16.64])(P<0.000 1). The two groups showed no significant difference in safety. The price of Qizhi Weitong Granules+Mosapride was higher than that of Mosapride alone. The ICER was 640.29 CNY, 1 506.67 CNY lower than the willingness-to-pay threshold. The sensitivity analysis showed that the analysis results were relatively stable. Thus, Qizhi Weitong Granules+Mosapride is safe, effective, and economical in the treatment of functional dyspepsia, which should be further promoted in clinical settings.
