Evidence mapping of clinical research on 20 Chinese patent medicines for hypertension.
10.19540/j.cnki.cjcmm.20220602.501
- Author:
Yi-Fei WANG
1
;
Li-Jun GUO
2
;
Feng GAO
3
;
Zhi-Bo ZHANG
1
;
Gao-Can REN
3
;
Xiao-Chang MA
2
Author Information
1. Graduate School of Beijing University of Chinese Medicine Beijing 100029, China.
2. National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
3. Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
- Publication Type:Review
- Keywords:
Chinese patent medicine;
evidence mapping;
evidence-based medicine;
hypertension
- MeSH:
China;
Drugs, Chinese Herbal/therapeutic use*;
Female;
Humans;
Hypertension/drug therapy*;
Medicine, Chinese Traditional;
Nonprescription Drugs;
Pregnancy;
Quality of Life
- From:
China Journal of Chinese Materia Medica
2022;47(18):5097-5105
- CountryChina
- Language:Chinese
-
Abstract:
In this study, evidence mapping was employed to sort out and summarise the evidence from clinical studies of Chinese patent medicines for hypertension and to understand the evidence distribution in related studies. Chinese patent medicines for hypertension were searched from Medicine Catalogue for National Basic Medical Insurance, Employment Injury Insurance, and Maternity Insu-rance(2021) and Chinese Pharmacopoeia(2020). Relevant articles(published from January 1, 2016 to February 14, 2022) were retrieved from Cochrane Library, PubMed, Web of Science, CNKI, Wanfang, VIP, and SinoMed. Then, the evidence distribution was analysed based on description, tables, and bubble charts. A total of 31 Chinese patent medicines were identified and 20 were finally included, involving 111 articles. The basic information of the 20 Chinese patent medicines, the number of related articles, the hypertension staging and traditional Chinese medicine(TCM) syndrome types of the subjects, sample size, interventions, and outcome indicators were compared. The results showed Chinese patent medicines with the function of pacifying liver and eliminating wind were frequently studied, and most of them were single-center, small-sample, short-period randomized controlled trials. They failed to highlight the key and advantages of TCM. A wide variety of outcome indicators were involved, and in addition to blood pressure, surrogate outcome indicators and composite outcome indicators were emphasized. However, health economic indicators, quality of life, and damage to target organs such as blood vessels and heart, were rarely used.
