Comparative study on intestinal absorption kinetics of main active components in Sini Decoction and its separated recipes.
10.19540/j.cnki.cjcmm.20220421.701
- Author:
Fei GAO
1
;
Fei ZHOU
1
;
Shuai GAN
1
;
Ya-Lan CHEN
1
;
Shu FU
1
;
Mei-Si LIN
2
;
Chao-Mei FU
1
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resource, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
2. State Key Laboratory of Southwestern Chinese Medicine Resource, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China School of Acupuncture and Moxibustion, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610097, China.
- Publication Type:Journal Article
- Keywords:
Aconiti Lateralis Radix Praeparata;
Glycyrrhizae Radix et Rhizoma;
Sini Decoction;
Zingiberis Rhizoma;
completed prescription;
in situ intestinal perfusion;
separated recipe
- MeSH:
Aconitine/analogs & derivatives*;
Aconitum;
Alkaloids;
Animals;
Catechols;
Drugs, Chinese Herbal;
Fatty Alcohols;
Glycyrrhizic Acid;
Intestinal Absorption;
Kinetics;
Rats
- From:
China Journal of Chinese Materia Medica
2022;47(18):5064-5070
- CountryChina
- Language:Chinese
-
Abstract:
This paper aims to study the difference in the intestinal absorption kinetics of main active components of Sini decoction and its separated recipes and explain the scientificity and rationality of the compatibility of Sini Decoction. A in situ intestinal perfusion rat model was established to evaluate the differences in the absorption of benzoylmesaconine, benzoylaconine, benzoylhypacoitine, mesaconitine, hypaconitine, glycyrrhizic acid, liquiritin and 6-gingerol from Sini Decoction and its separated recipes in the duodenum, jejunum and ileum by high performance liquid chromatography(HPLC). The results indicated that the Sini Decoction group was superior to the Aconiti Lateralis Radix Praeparata group in terms of absorption degree and rate for aconitum alkaloids. The absorption of benzoylmesaconine and hypaconitine in the duodenum, jejunum and ileum was faster and stronger in the Sini Decoction group(P<0.05). The absorption degree of glycyrrhizic acid in the duodenum was significantly higher in the Sini Decoction group than in the Glycyrrhizae Radix et Rhizoma group and the Glycyrrhizae Radix et Rhizoma-Zingiberis Rhizoma group(P<0.05). The absorption rate and degree of 6-gingerol in the ileum in the Sini Decoction group were significantly higher than those in the Zingiberis Rhizoma group(P<0.05). In short, Zingiberis Rhizoma and Glycyrrhizae Radix et Rhizoma can promote the absorption of aconitum alkaloids in different intestinal segments, which reflects the scientific composition of Sini Decoction.
