Two new steroidal alkaloids from ripe berries of Solanum nigrum.
10.19540/j.cnki.cjcmm.20220506.205
- Author:
Yu-Ke YANG
1
;
Liang-Yu LIU
1
;
Wen-Yi WANG
2
;
Jian-Nong WANG
1
;
Li LIN
1
;
Jian-Xun LIU
1
Author Information
1. Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
2. College of Pharmacy, Fujian University of Traditional Chinese Medicine Fuzhou 350122, China.
- Publication Type:Journal Article
- Keywords:
Solanum nigrum;
antitumor activity;
chemical constituent;
steroidal alkaloid
- MeSH:
Alkaloids/analysis*;
Ethanol;
Fruit/chemistry*;
Molecular Structure;
Plant Extracts/chemistry*;
Saponins/analysis*;
Silica Gel/analysis*;
Solanum/chemistry*;
Solanum nigrum/chemistry*;
Steroids/pharmacology*
- From:
China Journal of Chinese Materia Medica
2022;47(18):4966-4971
- CountryChina
- Language:Chinese
-
Abstract:
Two previously undescribed steroidal alkaloids, compounds 1-2, along with two known ones(3-4), were isolated from the 80% ethanol extract of ripe berries of Solanum nigrum by chromatographic methods, including silica gel, ODS, and HPLC. Based on spectroscopic and chemical evidence, including IR, NMR, and HR-ESI-MS data, the structures of the isolated compounds were identified as 12β,27-dihydroxy solasodine-3-O-β-D-glucopyranoside(1), 27-hydroxy solasodine-3-O-β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside(2), solalyraine A(3), and 12β,27-dihydroxy solasodine(4). Compounds 1-2 were tested for their potential effects against the proliferation of A549 cells, which revealed that compounds 1-2 had weak cytotoxic activity.
