A new isoflavone from Dalbergia odorifera and inhibitory activity of its tyrosinase.
10.19540/j.cnki.cjcmm.20220422.202
- Author:
Suet CHEUNG
1
;
Wan FANG
2
;
Xiao-Qing LI
1
;
Rui WANG
1
;
Shi-Kai YAN
1
;
Hui-Zi JIN
1
Author Information
1. School of Pharmacy, Shanghai Jiao Tong University Shanghai 200240, China.
2. Peking-Tsinghua Center for Life Sciences, Peking University Beijing 100871, China.
- Publication Type:Journal Article
- Keywords:
Dalbergia odorifera;
flavonoids;
tyrosinase inhibition
- MeSH:
Dalbergia/chemistry*;
Ethanol;
Flavonoids/chemistry*;
Genistein;
Isoflavones/pharmacology*;
Monophenol Monooxygenase;
Plant Extracts/pharmacology*;
Silica Gel;
Solvents
- From:
China Journal of Chinese Materia Medica
2022;47(18):4959-4965
- CountryChina
- Language:Chinese
-
Abstract:
Twelve flavonoids were isolated and purified from the ethyl acetate fraction of 95% ethanol extract of Dalbergia odorifera by heat reflux extraction, solvent extraction, recrystallization, normal phase silica gel, Sephadex LH-20, MCI gel and HPLC methods. The structures were identified with multiple spectroscopic methods, including 1 D-NMR, 2 D-NMR and MS. The compounds were identified as 6,7,8-trimethoxy-5,4'-dihydroxy isoflavone(1), medicarpin(2), 7,2'-dihydroxy-4'-methoxy-isoflavanol(3), biochanin A(4), prunetin(5), genistein(6), pratensein(7), 3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one(8), tectorigenin(9), irisolidone(10), vestitol(11), and formononetin(12). Compound 1 was a new isoflavone, and compound 8 was isolated from D. odorifera for the first time. The results showed that compounds 1-3 had inhibitory effects on tyrosinase, with inhibition rates of 35.58%, 38.63% and 51.34% at the concentration of 1.0 mmol·L~(-1), respectively.
