Chemome profiling of Qijiao Shengbai Capsules by UPLC-IT-TOF-MS.
10.19540/j.cnki.cjcmm.20220328.301
- Author:
Qian WANG
1
;
Xia XU
1
;
Ke ZHANG
1
;
Shi-Lin ZHANG
2
;
Li LIU
2
;
Qing WU
3
;
Peng-Fei TU
1
;
Yue-Lin SONG
1
;
Yun-Fang ZHAO
1
;
Jun LI
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.
2. Guizhou Hanfang Pharmaceutical Co., Ltd. Guiyang 550000, China.
3. Guizhou Key Laboratory of Mountainous Environment Information System and Environment Protection, Guizhou Normal University Guiyang 550001, China.
- Publication Type:Journal Article
- Keywords:
Qijiao Shengbai Capsules;
UPLC-IT-TOF-MS;
chemome profiling;
flavonoids;
quality evaluation
- MeSH:
Acetonitriles;
Alkaloids;
Capsules;
Chromatography, High Pressure Liquid;
Coumarins/analysis*;
Drugs, Chinese Herbal/chemistry*;
Flavonoids/analysis*;
Formates;
Proanthocyanidins/analysis*;
Purines;
Saponins;
Tandem Mass Spectrometry
- From:
China Journal of Chinese Materia Medica
2022;47(18):4938-4949
- CountryChina
- Language:Chinese
-
Abstract:
Qijiao Shengbai Capsules(QJ) are a common Miao medicine serving as an adjuvant cancer therapy in clinical practice.QJ consists of seven medicinal materials such as Astragalus membranaceus and Lespedeza buergeri.Its chemical components have not been clarified and the quality control needs to be improved.In this study, LC-IT-TOF-MS was used to comprehensively collect MS~1 and MS~2 fragment information of QJ and rapidly identify the chemical compositions.The chromatographic separation was performed on the Capcell core ADME column(2.1 mm×150 mm, 2.7 μm) with 0.1% formic acid aqueous solution(A) and acetonitrile(B) as mobile phases for gradient elution.High-resolution mass spectrometric information was obtained by scanning in the positive and negative ion ESI modes.A total of 107 compounds were structurally identified according to the deduced MS fragmentation patterns and comparison with standards and data reported in the literature, including 54 flavonoids, 16 phthalides, 13 alkaloids, 12 phenolic acids, 7 saponins, 2 coumarins, 2 condensed tannins, and 1 purine.This study clarified the chemical composition of QJ and provided references for the improvement of its quality standards and the elucidation of its medicinal substances.
