Preparation and characterization of near-infrared responsive sinomenine hydrochloride reservoir microneedles.
10.19540/j.cnki.cjcmm.20220411.301
- Author:
Jing-Yan WANG
1
;
Yan-Ju ZHANG
2
;
Huan ZHANG
2
;
Wen-Wen ZHAO
2
;
Zong-Yang LIU
2
;
Hai-Lun WANG
2
;
Dong MEI
2
;
Qing WU
3
Author Information
1. National Center for Children's Health, Beijing Children's Hospital, Capital Medical University Beijing 100045, China School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100102, China.
2. National Center for Children's Health, Beijing Children's Hospital, Capital Medical University Beijing 100045, China.
3. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100102, China.
- Publication Type:Journal Article
- Keywords:
methoxy poly(ethylene glycol) poly(caprolactone)(mPEG-PCL) copolymer;
microneedle;
near-infrared response;
sinomenine hydrochloride;
transdermal absorption
- MeSH:
Drug Delivery Systems/methods*;
Drug Liberation;
Indocyanine Green;
Morphinans;
Needles;
Polyethylene Glycols
- From:
China Journal of Chinese Materia Medica
2022;47(18):4919-4926
- CountryChina
- Language:Chinese
-
Abstract:
The present study designed and prepared near-infrared responsive sinomenine hydrochloride(SIN) reservoir microneedles and evaluated the feasibility of this type of microneedles in increasing the drug loading and transdermal absorption by characterizing their mechanical properties and in vitro release characteristics.SIN was selected as the model drug, and methoxy poly(ethylene glycol) poly(caprolactone)(mPEG-PCL) copolymers and indocyanine green(ICG) were employed as amphiphilic block copolymers and light inductor to prepare near-infrared responsive nanoparticles.Based on the preparation principle of bubble microneedles, near-infrared responsive SIN reservoir microneedles were designed and prepared.The features of the near-infrared responsive SIN reservoir microneedles were characterized by measuring the morphology, length, mechanical properties, and skin penetration of microneedles.Meanwhile, the drug release performance of reservoir microneedles was evaluated by in vitro release assay.The results showed that the prepared SIN microneedles were conical, with an exposed tip height of about 650 μm.Each needle could load about 0.5 mg of drugs per square centi-meter, and this type of microneedle showed good mechanical properties and performance in skin penetration.The results of the in vitro release assay showed that the 24 h cumulative release per unit area and release rate of the microneedle were 825.61 μg·cm~(-2) and 74.3%, respectively, which indicated that its release kinetics was in line with the first-order kinetic model.This study preliminarily proved that the reservoir microneedle could effectively increase the drug loading with good mechanical properties and release perfor-mance.
