Efficacy evolution of bear bile and related research on components.
10.19540/j.cnki.cjcmm.20220527.601
- Author:
Xin-Yue LI
1
;
Fang-Fang SU
1
;
Chao JIANG
2
;
Wei ZHANG
2
;
Feng WANG
3
;
Qing ZHU
3
;
Guang YANG
4
Author Information
1. College of Pharmacy, Hebei University of Chinese Medicine Shijiazhuang 050200, China.
2. China Academy of Chinese Medical Sciences Beijing 100700, China.
3. Chongqing Kingbear Biotechnology Co., Ltd. Chongqing 404100, China.
4. College of Pharmacy, Hebei University of Chinese Medicine Shijiazhuang 050200, China China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
bear bile;
chemical composition;
efficacy and indications;
pharmacological action;
transformed bear bile powder
- MeSH:
Animals;
Bile/metabolism*;
Bile Acids and Salts;
Humans;
Medicine, Chinese Traditional;
Powders;
Ursidae/metabolism*
- From:
China Journal of Chinese Materia Medica
2022;47(18):4846-4853
- CountryChina
- Language:Chinese
-
Abstract:
Animal medicine is an important part of traditional Chinese medicine(TCM). Bear bile is one of the rare animal-derived medicinal materials with the functions of clearing the liver, promoting bile secretion, calming the liver, relieving convulsions, clearing heat, and removing toxins. From the Jin Dynasty to the Tang Dynasty, bear bile was mainly used to treat internal diseases, surgical diseases, and pediatric diseases with limitations. At present, bear bile has been used to treat various diseases in pediatrics, gynecology, internal medicine, and surgery. Studies on the chemical constituents and pharmacological effects of bear bile mostly focused on bile acids. Although the non-bile acids also showed certain pharmacological effects, their mechanism of action was less investigated. At present, the source animals of bear bile are national second-class protected animals. Obtaining transformed bear bile powder through biotransformation is expected to alleviate the shortage of bear bile resources to a certain extent. Although related research on bear bile substitutes has protected bear bile resources, there are problems in functional quantification and modern interpretation. It is necessary to sort out the functions and indications of bear bile recorded in ancient books according to related modern research. This study firstly reviewed the evolution of bear bile functions and indications, analyzed the chemical components of bear bile, sorted out the relevant records of the efficacy and clinical application of bear bile in ancient books, and summarized the research progress in the safety of bear bile based on the modern pharmacological effects and clinical applications of bear bile, which is conducive to the clarification of modern efficacy and functional quantification of bear bile and the tentative exploration of the modern interpretation of bear bile.
