Metabolites of endophytic fungus Nigrospora sphaerica S5 from Myoporum bontioides.
10.19540/j.cnki.cjcmm.20220418.203
- Author:
Jia-Chun CAI
1
;
Qing-Qing LI
2
;
Jun-Wei LIU
1
;
Xue-Fen ZHENG
1
;
Nan WANG
1
;
Chun-Yuan LI
1
;
Ya-Hong XIONG
1
Author Information
1. Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University Guangzhou 510642, China.
2. Guangdong Xinkenong Biotechnology Co., Ltd. Shaoguan 512000, China.
- Publication Type:Journal Article
- Keywords:
Myoporum bontioides;
antibacterial activity;
endophytic fungus;
metabolites
- MeSH:
Alkaloids;
Anti-Bacterial Agents/pharmacology*;
Ascomycota/chemistry*;
Escherichia coli;
Formaldehyde;
Indoles/pharmacology*;
Lactones;
Molecular Structure;
Myoporum/microbiology*;
Phenols;
Pyrazines;
Sesquiterpenes
- From:
China Journal of Chinese Materia Medica
2022;47(17):4658-4664
- CountryChina
- Language:Chinese
-
Abstract:
The endophytic fungus Nigrospora sphaerica S5 derived from the semi-mangrove plant Myoporum bontioides was fermented. Its metabolites were purified by column chromatography. Nine compounds were obtained and identified as terezine P(1), 3-(1-hydroxyethyl)-4-methyl dihydrofuran-2(3H)-one(2), methylhydroheptelidate(3), hydroheptelidic acid(4), 5, 7-dimethoxy-4, 6-dimethylphthalide(5),(3R,4S)-(-)-4-hydroxymellein(6), pestalopyrone(7), indole-3-formaldehyde(8) and p-hydroxybenzaldehyde(9) by spectroscopic techniques. Terezine P(1) was a new alkaloid belonging to the terezine class with a pyrazine ring. Compounds 2-7 were lactones, of which 3 and 4 belonged to sesquiterpenes. Compounds 8 and 9 were indole alkaloids and phenols, respectively. Compounds 3-6 were purified from Nigrospora sp. for the first time. These compounds showed different degrees of antibacterial activity against Staphylococcus aureus, Escherichia coli of O6 serotype and E. coli of O78 serotype.
