Ginkgo biloba Ketone Ester Tablets with different release rates prepared by fused deposition modeling 3D printing technology.
10.19540/j.cnki.cjcmm.20211124.301
- Author:
Yong-Yuan LI
1
;
Chen CHEN
1
;
Hai-Xia WANG
2
;
Bei-Bei XIANG
3
;
Zheng LI
2
Author Information
1. College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
2. College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
3. School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
- Publication Type:Journal Article
- Keywords:
3D printing;
Ginkgo biloba ketone ester;
fused deposition;
personalized;
release rate
- MeSH:
Carboxymethylcellulose Sodium;
Esters;
Excipients/chemistry*;
Ginkgo biloba;
Ketones;
Polyethylene Glycols/chemistry*;
Printing, Three-Dimensional;
Tablets/chemistry*;
Technology, Pharmaceutical/methods*
- From:
China Journal of Chinese Materia Medica
2022;47(17):4643-4649
- CountryChina
- Language:Chinese
-
Abstract:
The present study prepared a new type of Ginkgo biloba ketone ester(GBE50) preparation from polyethylene glycol and croscarmellose sodium with good biocompatibility and a certain viscosity by fused deposition modeling(FDM)-type 3D printing technique. Firstly, a cylindrical 3D printing model with a diameter of 9.00 mm and a height of 4.50 mm was established. Subsequently, the 3D-GBE50 preparations with three paths(concentric, zigzag, and grid), different layer heights, and different filling gaps were designed and prepared after the optimization of the proportions of excipients. The morphology, size, chemical properties, and dissolution activity of the 3D-GBE50 preparations were fully characterized and investigated. The results showed that 3D-GBE50 preparations had smooth appearance, clear texture, standard friability, good thermal stability, and stable chemical properties. Moreover, the printing path, layer height, and filling gap were directly related to the release rate of 3D-GBE50 preparations. The dissolution of 3D-GBE50 tablets with zigzag printing path was the fastest, while the dissolution rates of 3D-GBE50 tablets with concentric circle and grid-shaped printing paths were slower than that of commercially available G. biloba Ketone Ester Tablets. In addition, the dissolution of 3D-GBE50 tablets was faster with higher layer height and wider filling gap. As revealed by the results, th FDM-type 3D printing technique can flexibly regulate the drug release activity via controlling the printing parameters, providing effective ideas and methods for the pre-paration of personalized pharmaceutical preparations.
