Theoretical innovation of component-based Chinese medicine and its exemplary practice: the study on creating Guanxinning Tablets.
10.19540/j.cnki.cjcmm.20220804.301
- Author:
Yi-Yu CHENG
1
;
Yi WANG
1
;
Li LIU
2
;
Xiao-Ping ZHAO
3
;
Yi ZHONG
4
;
Ming HUANG
5
;
Bo-Li ZHANG
5
Author Information
1. College of Pharmaceutical Sciences, Zhejiang University Hangzhou 310058, China State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
2. Chiatai Qingchunbao Pharmaceutical Co., Ltd. Hangzhou 310023, China.
3. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China College of Basic Medical Sciences,Zhejiang Chinese Medical University Hangzhou 310053, China.
4. College of Pharmaceutical Sciences, Zhejiang University Hangzhou 310058, China.
5. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
- Publication Type:Journal Article
- Keywords:
Guanxinning Tablets;
component with efficacy;
component-based Chinese medicine;
creation of modern Chinese medicine;
efficacy entity;
process quality controllability
- MeSH:
Artificial Intelligence;
Drugs, Chinese Herbal/pharmacology*;
Medicine, Chinese Traditional;
Quality Control;
Tablets
- From:
China Journal of Chinese Materia Medica
2022;47(17):4545-4550
- CountryChina
- Language:Chinese
-
Abstract:
Upholding the wisdom of traditional Chinese medicine that the therapeutic principle, method, formula and medicine are coherent with each other, we propose the technical methodology for intelligent creation of component-based Chinese medicine by integrating multidisciplinary knowledge such as artificial intelligence, pharmaceutical informatics, system pharmacology and phytochemistry. Taking the creation of Guanxinning Tablets as an example, we expound the technical principle for creating component-based Chinese medicine and briefly describe the design method for optimizing the entity of Chinese medicine efficacy by rational combination of active components. Our research sought to "clarify and explain" the mechanism of its clinical treatment action through multi-modal and multi-scale systematic pharmacology studies. This work emphatically demonstrates the pilot workshop and engineering validation platform based on the intelligent simulation of whole production process, and outlines the design principles of the intelligent production line for innovative Chinese medicine. The results of industrial research show that the ourself established method for evaluating the process quality controllability and intelligent production line can be applied to manufacturing Guanxining Tablets with high quality. Through the innovative research of multidisciplinary cross-border integration, the present work explored a new way for the creation of modern Chinese medicine.
