Dual modulating effects of hydrogen sulfide on gastrointestinal tract and efficacy-toxicity transformation of hydrogen sulfide-mediated drugs.
10.19540/j.cnki.cjcmm.20220410.601
- Author:
Jin-Gao YU
1
;
Na LI
1
;
Zheng WANG
2
;
Yu-Jing HUI
2
;
Yu HE
2
;
Xiu-He FAN
2
Author Information
1. Co-construction Collaborative Innovation Center for Chinese Medicine Resources Industrialization by Shaanxi & Education Ministry/State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation)/Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine Xianyang 712046, China Key Laboratory of Pharmacodynamic Mechanism and Material Basis of Traditional Chinese Medicine, Shaanxi Provincial Administration of Traditional Chinese Medicine,Shaanxi University of Chinese Medicine Xianyang 712046, China.
2. Co-construction Collaborative Innovation Center for Chinese Medicine Resources Industrialization by Shaanxi & Education Ministry/State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation)/Shaanxi Innovative Drug Research Center, Shaanxi University of Chinese Medicine Xianyang 712046, China.
- Publication Type:Journal Article
- Keywords:
donor;
efficacy-toxicity transformation;
gastrointestinal tract;
hydrogen sulfide;
mechanism;
metabolic homeostasis;
microflora;
toxicity
- MeSH:
Gastrointestinal Tract;
Hydrogen Sulfide/pharmacology*;
Signal Transduction
- From:
China Journal of Chinese Materia Medica
2022;47(15):3986-3993
- CountryChina
- Language:Chinese
-
Abstract:
Hydrogen sulfide is one of the most important signal transduction molecules in the body. Its anabolism and catabolism in the gastrointestinal tract(GT) are extremely high, and its role in the physiological and pathological process of the GT is fairly complicated. The study reviewed recent literature on hydrogen sulfide and GT, and proposed that hydrogen sulfide exerted dual modulating effects in the GT; specifically, it promoted the functions of the GT at low concentrations while damaged the GT at high concentrations. Hydrogen sulfide donors or metabolic modifiers exerted their therapeutic effects by restoring the metabolic homeostasis of hydrogen sulfide, and extended their efficacy to other tissues through hydrogen sulfide related gut-axis. Additionally, drugs could deviate hydrogen sulfide metabolism from the normal state due to their instability of structure, local over exposure and/or excessive pharmacological effects, thus inducing toxic and side effects or transforming therapeutic effects into toxic and side effects. This study provided references for the deep research on physiological and pathological mechanisms of hydrogen sulfide and facilitated the development of hydrogen sulfide-related drugs and discovery of their toxicity and efficacy mechanism.
