Two Different Penicillin Preparations in the Treatment of Gonorrhhea.
- Author:
Jang Ho BYUN
;
Choong Sang KIM
;
Joong Hwan KIM
- Publication Type:Original Article
- MeSH:
Appointments and Schedules;
Far East;
Gonorrhea;
Humans;
Korea;
Male;
Neisseria;
Neisseria gonorrhoeae;
Oxidoreductases;
Penicillin G Procaine;
Penicillins*;
Probenecid;
Procaine;
Sodium
- From:Korean Journal of Dermatology
1981;19(3):253-259
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Penicillin is still the first choice of drug in the treatment of gonorrhea. The ever lowering sensitivity of Neisseria gonorrhoeae to penicillin and the emergence of PPNG (Penicillinase Producing Neisseria Gonorrhoeae) in the Far East and other parts of the world neceessitate reapprisal of treatrnent schedules with penicillin for gonococcal infections. In Korea, no authentical study in this regard has been done recently. The presence of intracellular gram r.egative diplococci in urethral smear as weIl as the presence of oxidase positive typical, round, convex, smooth, glistening, tratmslucent, greyish colonies of 0.5 to 2mm in diameter a 24 hours composed of grarn negative diplococci are used for presump'ive evidence of gonococccal infection 224 male patients with acnte uncomplicated gonococal infections were treated one of following regimens. Regimen A: 4.8mega unit combicillin (3.6mega unit procaine penicillin+l.2 mega unit sodium penicillin) i.m.. preceded by 1gm probenecid p.o., Regirnen B: 4.8 mega unit procaine penicillin i.m. preceded by 1gm probenecid P.O. Regimen A showed 14 failures(11.3% arnong 124. Regimen B showed 19 failures (19%) among 100 It is suggested that in Korea sesnsitivity to penicillin of Yeisseria gonorrhoeae is quite low.
