A new cyclopeptide from Selaginella tamariscina.
10.19540/j.cnki.cjcmm.20220421.204
- Author:
Xin-Jia YAN
1
;
Jing WEN
2
;
Yang SONG
3
;
Dong-Mei SHA
1
;
Ma-Li-Niu SHA
1
;
Shao-Shan ZHANG
1
;
Yuan LIU
1
Author Information
1. Institute of Qinghai-Tibetan Plateau, Southwest Minzu University Chengdu 610041, China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225, China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology Engineering Laboratory Chengdu 610225, China.
2. College of Pharmacy, Harbin University of Commerce Harbin 150076, China.
3. Shimadzu (China) Co., Ltd. Shanghai 200233, China.
- Publication Type:Journal Article
- Keywords:
Selaginella tamariscina;
cyclopeptide;
cytotoxicity;
selapeptin A;
structural identification
- MeSH:
Chromatography, High Pressure Liquid;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Peptides, Cyclic/pharmacology*;
Selaginellaceae/chemistry*
- From:
China Journal of Chinese Materia Medica
2022;47(16):4391-4394
- CountryChina
- Language:Chinese
-
Abstract:
One new cyclopeptide was isolated from the ethyl acetate fraction of the 75% EtOH extract of Selaginella tamariscina by various column chromatography methods(HP-20, polyamide and semi-preparative HPLC). Its structure was identified as selapeptin A(1) by extensive spectroscopic analysis(HR-ESI-MS, 1 D and 2 D NMR). Compound 1 was evaluated for cytotoxic activities by MTT assay. It showed potent cytotoxic activity against B16 F10 with the inhibition rate of 51.57%±4.34% at 40 μmol·L~(-1) while had no impacts on MDA-MB-231 and MDA-MB-468 at 100 μmol·L~(-1).
