Sesquiterpenoids from Aquilariae Lignum Resinatum.
- Author:
Hang ZHANG
1
;
Jia-le MA
1
;
Ni-Li ZAN
1
;
Rong-Ye WANG
1
;
Yun-Fang ZHAO
1
;
Yue-Lin SONG
1
;
Jiao ZHENG
1
;
Peng-Fei TU
1
;
Hui-Xia HUO
1
;
Jun LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Aquilariae Lignum Resinatum; chemical constituent; gastric mucosal cell protection; sesquiterpenoids
- MeSH: Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Molecular Structure; Sesquiterpenes/chemistry*
- From: China Journal of Chinese Materia Medica 2022;47(16):4385-4390
- CountryChina
- Language:Chinese
- Abstract: Eight sesquiterpenoids were isolated from petroleum ether extract of Aquilariae Lignum Resinatum by various column chromatography techniques including silica gel, ODS, and semi-preparative HPLC. Their structures were identified on the basis of physicochemical properties, UV, IR, MS, and NMR spectroscopic data as(4S,5S,7R,10S)-5,7-dihydroxy-11-en-eudesmane(1),(7R,10S)-eudesma-4-en-11,15-diol(2),(2R,4S,5R,7R)-2-hydroxyeremophila-9,11-dien-8-one(3), 7α-H-9(10)-ene-11,12-epoxy-8-oxoeremophilane(4),(+)-9β,10β-epoxyeremophila-11(13)-en(5), 4(14)-eudesmene-8α,11-diol(6), 12,15-dioxo-selina-4,11-dien(7), and 2β,8 aα-dihydroxy-11-en-eremophilane(8). Compounds 1 and 2 are new compounds, and their absolute configurations were determined by calculating ECD. Compounds 1, 4, and 6-8 could significantly improve taurocholic acid(TCA)-induced gastric mucosal GES-1 cell injury at a concentration of 20 μmol·L~(-1), and the cell protection rates were 23.51%±2.79%, 16.10%±1.25%, 24.45%±4.89%, 17.48%±2.93%, and 21.44%±2.39%, respectively.
