Research advances in prevention and treatment of cerebral ischemia-reperfusion injury by targeting mitochondrial quality control.
10.19540/j.cnki.cjcmm.20220217.702
- Author:
Xuan WEI
1
;
Ji-Yong LIU
2
;
Wen-Li ZHANG
3
;
Zhi-Gang MEI
1
Author Information
1. Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine Changsha 410208, China.
2. Hunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics,Hunan University of Chinese Medicine Changsha 410208,China.
3. School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China.
- Publication Type:Review
- Keywords:
acupuncture and moxibustion;
cerebral ischemia-reperfusion;
mitochondrial quality control;
stroke;
traditional Chinese medicine(TCM)
- MeSH:
Brain Ischemia/prevention & control*;
Calcium/metabolism*;
Humans;
Ischemic Stroke;
Mitochondria/pathology*;
Reactive Oxygen Species/metabolism*;
Reperfusion Injury/prevention & control*
- From:
China Journal of Chinese Materia Medica
2022;47(16):4305-4313
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia-reperfusion injury(CIRI) is an important factor hindering the recovery of ischemic stroke patients after blood flow recanalization. Mitochondria, serving as the "energy chamber" of cells, have multiple important physiological functions, such as supplying energy, metabolizing reactive oxygen species, storing calcium, and mediating programmed cell death. During CIRI, oxidative stress, calcium overload, inflammatory response, and other factors can easily lead to neuronal mitochondrial dyshomeostasis, which is the key pathological link leading to secondary injury. As reported, the mitochondrial quality control(MQC) system, mainly including mitochondrial biosynthesis, kinetics, autophagy, and derived vesicles, is an important endogenous mechanism to maintain mitochondrial homeostasis and plays an important protective role in the damage of mitochondrial structure and function caused by CIRI. This paper reviewed the mechanism of MQC and the research progress on MQC-targeting therapy of CIRI in recent 10 years to provide theoretical references for exploring new strategies for the prevention and treatment of ischemic stroke with traditional Chinese medicine.
