Spectral characteristics of sesquiterpene pyridine alkaloids from Tripterygium plants.
10.19540/j.cnki.cjcmm.20211207.202
- Author:
Jian-Gong YAN
1
;
Xian-Fu WU
2
;
Ming-Hui CHEN
2
;
Zhong DAI
2
;
Ya-Dan WANG
2
;
Shuang-Cheng MA
2
Author Information
1. National Institutes for Food and Drug Control Beijing 100050, China Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine Shijiazhuang 050200, China.
2. National Institutes for Food and Drug Control Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Tripterygium;
sesquiterpene pyridine alkaloids;
spectral characteristics;
structure features
- MeSH:
Alkaloids/pharmacology*;
Drugs, Chinese Herbal/pharmacology*;
Molecular Structure;
Pyridines/pharmacology*;
Sesquiterpenes;
Tripterygium/chemistry*
- From:
China Journal of Chinese Materia Medica
2022;47(16):4292-4304
- CountryChina
- Language:Chinese
-
Abstract:
Sesquiterpene pyridine alkaloids are important components in Tripterygium plants, possessing a wide range of pharmacological activities, such as anti-inflammation immunosuppression, anti-tumor, anti-virus, and deinsectization, and are of great research value. They are composed of highly oxidized dihydro-β-furansquiterpene and pyridine dicarboxylic acid through ester bonds. According to the structural characteristics of pyridine dicarboxylic acid fragments, they can be divided into various structural subtypes. Up to now, more than 110 sesquiterpene pyridine alkaloids have been isolated and identified from Tripterygium plants. This study reviewed the structural features and spectral(i.e., UV, IR, MS, and NMR) characteristics of sesquiterpene pyridine alkaloids and summarized the structural elucidation process in detail to provide references for their further research and development.
