Research progress on antitumor effect and molecular mechanism of capsaicin.
10.19540/j.cnki.cjcmm.20220421.601
- Author:
Xin-Yue ZHOU
1
;
Xia-Yang LIU
1
;
Zhuang LI
1
;
Xiao-Hong GUO
1
Author Information
1. School of Basic Medical Sciences, Hubei University of Chinese Medicine Wuhan 430065, China.
- Publication Type:Journal Article
- Keywords:
angiogenesis;
antitumor;
apoptosis;
capsaicin;
molecular mechanism
- MeSH:
Animals;
Antineoplastic Agents/therapeutic use*;
Apoptosis;
Capsaicin/therapeutic use*;
Capsicum;
Cell Line, Tumor;
Cell Proliferation;
Liver Neoplasms
- From:
China Journal of Chinese Materia Medica
2022;47(16):4277-4283
- CountryChina
- Language:Chinese
-
Abstract:
Capsaicin is a lipid-soluble vanillin alkaloid extracted from Capsicum plants in the Solanaceae family, which is the main active ingredient in capsicum, with multiple functions such as anti-inflammation, analgesia, cardiovascular expansion, and gastric mucosa protection. Recently, capsaicin has been confirmed as a potential antitumor compound. It can induce cell cycle arrest, inhibit cancer cell proliferation, metastasis, invasion, and angiogenesis, and promote apoptosis or autophagy in malignancy cell models and animal models of lung cancer, breast cancer, gastric cancer, and liver cancer. Meanwhile, capsaicin shows a synergistic antitumor effect when combined with other antitumor drugs such as sorafenib. Based on the recent literature on the antitumor effect of capsaicin, the present study analyzed the molecular mechanism of capsaicin in resisting tumors by inducing apoptosis and reviewed the effects of capsaicin in inducing tumor cell cycle arrest, inhibiting tumor cell proliferation, metastasis, and angiogenesis, and combating tumors with other drugs, thereby providing a theoretical basis for further research of capsaicin and its rational development and utilization.
