Advances in Mechanisms of Blood Brain Barrier Impairment Induced by Sleep Deprivation.
10.3881/j.issn.1000-503X.14302
- Author:
Ji-Xiang ZHU
1
;
Yu-Lin HUANG
1
;
Kun NI
1
;
Yue LIU
1
;
Zheng-Liang MA
1
Author Information
1. Department of Anesthesiology,Nanjing Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,China.
- Publication Type:Journal Article
- Keywords:
blood-brain barrier;
endothelial dysfunction;
sleep deprivation
- MeSH:
Humans;
Sleep Deprivation/complications*;
Blood-Brain Barrier;
Brain
- From:
Acta Academiae Medicinae Sinicae
2022;44(5):885-890
- CountryChina
- Language:Chinese
-
Abstract:
Sleep deprivation,the process and state of partial or complete lack of normal sleep caused by various factors,is prevalent at present.Seriously impairing the physical and mental health,sleep deprivation has become a public health problem that cannot be ignored.Studies have demonstrated that blood-brain barrier impairment is the key pathophysiological process of a variety of neurological diseases.Although clinical and basic studies have suggested that sleep deprivation can induce blood-brain barrier impairment,the underlying mechanisms remain to be elucidated.This review summarizes the advances in the mechanisms of blood-brain barrier impairment induced by sleep deprivation.
