Research Progress of Pleckstrin Homology Like Domain Family A Member 1 in Tumor.
10.3881/j.issn.1000-503X.14126
- Author:
Shi-Bo ZHAO
1
;
Han-Jun MA
1
;
Zhong-Gang WU
1
;
Bo LING
2
;
Guang-Bin YE
3
Author Information
1. School of Clinical Medicine,Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China.
2. School of Pharmacy,Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China.
3. School of Basic Medical Sciences,Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China.
- Publication Type:Journal Article
- Keywords:
biological characteristics;
pleckstrin homology like domain family A member 1;
research progress;
tumor
- MeSH:
Humans;
Female;
Transcription Factors/genetics*;
Phosphoproteins;
Blood Proteins;
Breast Neoplasms/genetics*
- From:
Acta Academiae Medicinae Sinicae
2022;44(5):863-867
- CountryChina
- Language:Chinese
-
Abstract:
Pleckstrin homology like domain family A member 1(PHLDA1) is also known as T-cell death-associated gene 51 (TDAG51).Studies have demonstrated that the abnormal expression of PHLDA1 is closely associated with the formation,development,and metastasis of tumors.We summarized the latest research advances in the structure and biological properties of PHLDA1,as well as the roles of PHLDA1 in multiple malignanttumors such as breast cancer,cancer,liver gastric cancer,liver cancer,melanoma,and osteosarcoma,aiming to comprehensively reveal the significance of PHLDA1 in the clinical diagnosis of tumors.
